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Table 1 Baseline sociodemographic, clinical, functional, radiologic characteristics of the patients

From: Functional respiratory impairment and related factors in patients with interstitial pneumonia with autoimmune features (IPAF): Multicenter study from NEREA registry

Variables

N = 79

Sociodemographic

 Women, n (%)

53 (79)

 Mean age at ILD diagnosis ± SD, years

66.5 ± 11

 Smokers (active and formers), n (%)

11 (14)

BMI, median [p25-75]

26.5 [24–31.5]

Hospital center, n (%)

 FJD

34 (43)

 HCSC

23 (29)

 HiLe

6 (7, 6)

 HIS

2 (2, 5)

 HPH

4 (5)

 HUG

6 (7.6)

 HULP

4 (5.1)

Comorbidity n (%) (n = 74)

 Total

51 (68.9)

Comorbidity, n (%) (n = 74)

 Hypertension

27 (36.5)

 Cholesterol

22 (29.7)

 Diabetes Mellitus

5 (6.7)

 Ischemic heart disease

9 (12.2)

 Cerebrovascular disease

4 (5.4)

 Peripheral vascular disease

2 (2.7)

 Hypothyroidism

9 (12.2)

 Liver disease

4 (5.4)

 History of cancer

7 (9.5)

 COPD-Bronchiectasis

8 (10.8)

 Renal failure (dialysis)

2 (2.7)

 GER

4 (5.4)

 History of cancer

7 (9.5)

ILD associated (HRCT), n (%)

 Fibrotic (n = 54)

23 (42.6)

 Emphysema (n = 54)

10 (18.5)

 PHT (n = 63)

5 (8)

PTF parameters, median [p25–75]

 FVC% (n = 79)

88 [74–101]

 DLCO% (n = 68)

64 [50–81.5]

Radiographic ILD pattern (HRCT) n (%)

 UIP

29 (36.7)

 NSIP

37 (46.8)

 Others

13 (16.5)

Laboratory, median [p25–75]

 ESR

34 [17–50]

Therapy previous IPAF, n (%)

 Glucocorticoids -DAMRDs

26 (33)

Regimen of therapy during the follow-up, n (%)

 None

18 (22.7)

 Glucocorticoids and/or DMARDs and/or Anti-Fibrotic

61 (77.2)

 Glucocorticoids alone

5 (6.3)

 DMARDs and/or Anti-Fibrotic

9 (11.5)

 Glucocorticoids and DMARDs and/or Anti-Fibrotic

47 (59.5)

  1. Description of the therapy used previous and along the study follow-up
  2. Centers: Hospital Clínico San Carlos (HCSC), Hospital Infanta Leonor (HiLe), Hospital Infanta Sofía (HIS); Hospital Puerta de Hierro (HPH) Hospital Getafe (HUG), Hospital Universitario de la Paz (HULP), and Hospital Fundación Jiménez Díaz (FJD). COPD: chronic Obstructive pulmonary disease; GER: gastro esophageal reflux; ILD: interstitial lung disease; PTF: Pulmonary functional tests; PHT: pulmonary hypertension; FVC%: predicted forced vital capacity; DLCO%: predicted diffusing capacity of the lungs for carbon monoxide; UIP: usual interstitial pneumonia; NSIP: non specific interstitial pneumonia and others: indeterminate (5); lymphoid interstitial pneumonia (LIP) (1); cryptogenic organizing pneumonia (COP) (1); alveolar pattern (1), mixed pattern [NSIP-COP (2), alveolar-COP (3)]; ESR: erythrocyte sedimentation rate; DMARDs: disease modifying antirheumatic drugs