Table 1 Characteristics of the three study groups
From: Distinct COPD subtypes in former smokers revealed by gene network perturbation analysis
| Â | COPDGene discovery group | COPDGene validation group | MESA validation group | |||
|---|---|---|---|---|---|---|
| Â | Reference group | Case group | Reference group | Case group | Reference group | Case group |
Participants, n | 128 | 489 | 149 | 614 | 104 | 327 |
Age, yr, mean (SD) | 66.7 (8.8) | 70.1 (7.7) | 67.7 (8.6) | 69.5 (7.6) | 67.5 (8.3) | 70.1 (9.3) |
Sex, F, n (%) | 78 (60.9) | 216 (44.1) | 91 (61.1) | 290 (47.2) | 53 (51.0) | 137 (41.9) |
Race, Non-Hispanic White, n (%) | 111 (86.7) | 457 (93.5) | 138 (92.6) | 562 (91.5) | 45 (43.3) | 177 (54.1) |
Race, African American, n (%) | 17 (13.3) | 32 (6.5) | 11 (7.4) | 52 (8.5) | 18 (17.3) | 68 (20.8) |
Race, Hispanic, n (%) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 41 (39.4) | 82 (25.1) |
GOLD stage 0, n (%) | 128 (100) | 145 (29.7) | 149 (100) | 210 (34.2) | 104 (100) | 109 (33.3) |
PRISm, n (%) | NA | 62 (12.7) | NA | 84 (13.7) | NA | 0 |
GOLD stage 1, n (%) | NA | 57 (11.7) | NA | 74 (12.1) | NA | 98 (30.0) |
GOLD stage 2, n (%) | NA | 130 (26.6) | NA | 137 (22.3) | NA | 0 |
GOLD stage 3, n (%) | NA | 76 (15.6) | NA | 85 (13.9) | NA | 0 |
GOLD stage 4, n (%) | NA | 18 (3.7) | NA | 21 (3.4) | NA | 0 |
Smoking history, pack-year, mean (SD) | 37.2 (21.9) | 45.9 (25.6) | 35.5 (21.0) | 43.6 (23.4) | 12.7 (14.1) | 16.8 (20.2) |