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Table 2 Pleiotropy and heterogeneity tests of MR

From: Genetic association of circulating C-reactive protein levels with idiopathic pulmonary fibrosis: a two-sample Mendelian randomization study

Test

Method

Effect size

P

Heterogeneity

Cochran's Q test

58.745 (QMR Egger)

0.242

 

Cochran's Q test

61.238 (QIVW)

0.204

Pleiotropy

MR-Egger regression

− 0.016 (egger_intercept)

0.143

 

MR-PRESSO global test

64.970 (RSSobs)

0.170

  1. MR: Mendelian randomization; IVW: inverse variance weighted; RSS: residual sum of squares