Genetic association of circulating C-reactive protein levels with idiopathic pulmonary fibrosis: a two-sample Mendelian randomization study

Table 1 Causal effect of circulating CRP levels on IPF

Exposure	Outcome	N(SNP)	Method	OR (95% CI)	P
Circulating CRP	IPF	54	MR Egger	1.762 (1.232–2.521)	0.003
Circulating CRP	IPF	54	Weighted median	1.663 (1.170–2.364)	0.005
Circulating CRP	IPF	54	Inverse variance weighted	1.446 (1.128–1.854)	0.004
Circulating CRP	IPF	54	Simple mode	1.487 (0.619–3.573)	0.379
Circulating CRP	IPF	54	Weighted mode	1.660 (1.250–2.203)	0.001

CRP: C-reactive protein; IPF: idiopathic pulmonary fibrosis; SNP: single-nucleotide polymorphism; OR: odds ratio; CI: confidence interval

ISSN: 1465-993X