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Fig. 5 | Respiratory Research

Fig. 5

From: The main e-cigarette component vegetable glycerin enhances neutrophil migration and fibrosis in endotoxin-induced lung injury via p38 MAPK activation

Fig. 5

The inhibition of p38 MAPK activity attenuated neutrophil migration and fibrogenesis in VG-induced lung injury. Administration of a p38 MAPK inhibitor attenuated LPS and VG induced neutrophil migration and fibrogenesis. A–C Representative IHC images (above) and quantitative analysis summaries (below) showing LPS and VG induced increases in the expression of adhesion molecules VLA-4 (A) and VCAM-1 (B) and the expression of the central mediator of fibrogenesis TGF-β (C). Intraperitoneal administration of a p38 MAPK inhibitor countered these LPS and VG induced changes. *p < 0.05 vs. PBS, #p < 0.05 vs. respective group without the inhibitor; N = 6 per group

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Respiratory Research

ISSN: 1465-993X

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