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Fig. 4 | Respiratory Research

Fig. 4

From: The main e-cigarette component vegetable glycerin enhances neutrophil migration and fibrosis in endotoxin-induced lung injury via p38 MAPK activation

Fig. 4

The inhibition of p38 MAPK activity attenuated histopathological changes in VG-induced lung injury. LPS and VG induced pathological changes of ALI and pulmonary fibrotic changes in mice. The administration of a p38 MAPK inhibitor restored these changes. A Examination of H&E stained sections showed that intratracheal administration of LPS or VG induced pathological changes. Intraperitoneal administration of a p38 MAPK inhibitor attenuated ALI changes. B Masson's trichrome staining revealed that intratracheal administration of LPS or VG induced fibrotic changes. Intraperitoneal administration of a p38 MAPK inhibitor attenuated lung fibrosis changes. *p < 0.05 vs. PBS, #p < 0.05 vs. respective group without the inhibitor; N = 6 per group

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