Fig. 9

Molecules associated with an asthma network in the HDM mouse model. A Genes correlated with asthma pathogenesis. Nodes represent the molecules and lines indicate the relationship between two nodes. The description of the node shapes is displayed in the legends to the left side. The node color intensities show the expression level degrees between HDM mice relative to control. The downregulated molecules are in green and upregulated in pink or red. Dotted lines indicate relationships between these molecules and asthma, as predicted by the IPA findings. Red lines indicate predicted activation, yellow lines represent inconsistent findings in the literature, and grey lines mean the effect was unknown. B miRNA-gene network interactions. miRNAs are colored in red (upregulated) or green (downregulated), and mRNA targets are represented in the lower big circle of image 7B. Grey arrows indicate an association between miRNAs and their targets