Parameters | Baseline | Change to 3 months follow-up | Change to 6 months follow-up | ||||
---|---|---|---|---|---|---|---|
Mean ± standard deviation | n | Mean ± standard deviation | n | Mean ± standard deviation | n | ||
6-min walking distance, meters | 267.7 ± 110.1 | 6 | − 8.8 ± 62.4 | 6 | 4.7 ± 41.4 | 6 | |
N-terminal pro brain natriuretic peptide, pg/l | 4871.3 ± 6684.7 | 8 | − 453.4 ± 5268.5 | 8 | − 1159.6 ± 3446.2 | 8 | |
SaO2 [%] | 93.3 ± 2.4 | 12 | − 0.5 ± 4.1 | 12 | 1.3 ± 3.1 | 11 | |
Quality of Life (SF-36) | |||||||
Physical component score | 34.4 ± 16.7 | 8 | 8.0 ± 17.0 | 8 | 6.6 ± 13.8 | 10 | |
Mental component score | 45.1 ± 25.1 | 8 | 2.5 ± 29.8 | 8 | 1.0 ± 15.5 | 10 | |
Physical function | 19.4 ± 15.5 | 8 | 5.0 ± 11.0 | 8 | 4.0 ± 13.3 | 10 | |
Physical role performance | 12.5 ± 35.4 | 8 | 25. ± 37.8 | 8 | 20 ± 36.9 | 10 | |
Bodily pain | 65.1 ± 18.9 | 8 | 9.3 ± 25.4 | 8 | 8.5 ± 16.1 | 10 | |
General health | 40.1 ± 17.4 | 8 | − 2.3 ± 26.3 | 8 | − 1.3 ± 17.6 | 10 | |
Vitality | 35.0 ± 24.9 | 8 | 3.8 ± 24.9 | 8 | 2.0 ± 16.0 | 10 | |
Sovial functioning | 51.6 ± 33.1 | 8 | 4.8 ± 37.0 | 8 | − 1.3 ± 22.4 | 10 | |
Emotional role performance | 50.0 ± 53.5 | 8 | 0.0 ± 71.3 | 8 | 0.0 ± 47.1 | 10 | |
Mental health | 49.0 ± 20.3 | 8 | 6.5 ± 24.3 | 8 | 3.5 ± 19.9 | 10 | |
Lung function | |||||||
FVC (L) | 2.4 ± 0.6 | 7 | 0.2 ± 0.3 | 7 | 0.01 ± 0.4 | 7 | |
FVC /FEV1[%] | 73.3 ± 6.0 | 7 | 0.6 ± 4.2 | 7 | 2.7 ± 5.1 | 7 | |
FEV1 [L] | 1.9 ± 0.4 | 7 | 0.1 ± 0.1 | 7 | 0.04 ± 0.3 | 7 | |
PEF [L/sec] | 4.4 ± 1.5 | 7 | 0.2 ± 0.5 | 7 | 0.3 ± 0.6 | 7 | |
DLCO [%] | 50.1 ± 28.2 | 4 | 7.5 ± 8.3 | 4 | 0.13 ± 12.4 | 6 | |
TLC [L] | 5.2 ± 0.9 | 7 | − 0.4 ± 0.9 | 7 | − 0.2 ± 0.8 | 7 | |
Residual volume [L] | 2.7 ± 1.3 | 7 | − 0.4 ± 0.9 | 7 | 0.1 ± 0.9 | 7 | |
Echocardiography at rest | |||||||
sPAP [mmHg] | 82.0 ± 15.7 | 10 | − 9.2 ± 19.9 | 10 | − 9.0 ± 25.8 | 10 | |
RA area [cm2] | 23.2 ± 5.8 | 11 | 0.8 ± 6.6 | 11 | − 0.4 ± 6.3 | 10 | |
RV area [cm2] | 27.5 ± 6.2 | 11 | − 1.5 ± 5.9 | 11 | 2.4 ± 5.8 | 10 | |
TAPSE [cm] | 1.98 ± 0.61 | 11 | − 0.07 ± 0.35 | 11 | 0.09 ± 0.48 | 10 | |
Tei-index | 0.86 ± 0.32 | 8 | − 0.15 ± 0.19 | 8 | − 0.04 ± 0.23 | 7 | |
Right heart catherization | |||||||
mPAP [mmHg] | 58.3 ± 7.6 | 3 | − 6.7 ± 11.5 | 3 | |||
sPAP [mmHg] | 98.7 ± 11.8 | 3 | − 11.7 ± 20.2 | 3 | |||
dPAP [mmHg] | 36.6 ± 6.1 | 3 | − 3.3 ± 5.8 | 3 | |||
PVR [dyn × s × cm−5] | 8.2 ± 3.9 | 3 | − 0.6 ± 1.1 | 3 | |||
mRAP [mmHg] | 10.3 ± 4.6 | 3 | − 4.0 ± 6.9 | 3 | |||
PAWP [mmHg] | 10.3 ± 3.2 | 3 | − 2.7 ± 4.6 | 3 | |||
Cardiac output [l/min] | 6.4 ± 1.8 | 3 | 0.3 ± 0.5 | 3 | |||
Cardiac index [l × min × m−2] | 2.8 ± 0.5 | 3 | 0.03 ± 0.23 | 3 |