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Table 2 Prevalence of comorbidities in the entire cohort and the three clusters

From: Clusters of comorbidities in fibrotic hypersensitivity pneumonitis

Comorbidity

Entire cohort

(n = 211)

Cluster 1

(n = 99)

Cluster 2

(n = 65)

Cluster 3

(n = 47)

Total number of comorbidities (SD)

2.7 (2.1)

1.4 (1.3) **

4.2 (2.2) **

3.3 (1.4) *

Airway obstruction, n (%)

20 (9.5%)

11 (11.1%)

3 (4.6%)

6 (12.8%)

Obstructive sleep apnea, n (%)

19 (9.0%)

6 (6.1%)

9 (13.8%)

4 (8.5%)

Thromboembolic disorders, n (%)

10 (4.7%)

4 (4.0%)

2 (3.1%)

4 (8.5%)

Pulmonary hypertension, n (%)

20 (9.5%)

0 (0.0%) **

18 (27.7%) **

2 (4.3%)

Arterial hypertension, n (%)

117 (55.5%)

36 (36.4%) **

53 (81.5%) **

28 (59.6%)

Ischemic heart disease, n (%)

37 (17.5%)

1 (1.0%) **

35 (53.8%) **

1 (2.1%) **

Atrial fibrillation, n (%)

18 (8.5%)

5 (5.1%)

12 (18.5%) **

1 (2.1%)

Other arrythmias, n (%)

5 (2.4%)

1 (1.0%)

3 (4.6%)

1 (2.1%)

Heart failure, n (%)

25 (11.9%)

3 (3.0%) **

21 (32.3%) **

1 (2.1%) *

Heart valve disease, n (%)

8 (3.8%)

2 (2.0%)

6 (9.2%) *

0 (0.0%)

Cerebrovascular disease, n (%)

19 (9.0%)

4 (4.0%) *

12 (18.5%) **

3 (6.4%)

Peripheral artery disease, n (%)

8 (3.8%)

1 (1.0%)

4 (6.2%)

3 (6.4%)

Vascular disease, n (%)

2 (1.0%)

0 (0.0%)

2 (3.1%)

0 (0.0%)

Renal insufficiency, n (%)

7 (3.3%)

2 (2.0%)

5 (7.7%) *

0 (0.0%)

Gastro-esophageal reflux disease,

n (%)

50 (23.7%)

26 (26.3%)

10 (15.4%)

14 (29.8%)

Liver disease, n (%)

9 (4.3%)

4 (4.0%)

4 (6.2%)

1 (2.1%)

Hypothyroidism, n (%)

28 (13.3%)

0 (0.0%) **

5 (7.7%)

23 (48.9%) **

Osteoporosis, n (%)

26 (12.3%)

0 (0.0%) **

4 (6.2%)

22 (46.8%) **

Diabetes mellitus, n (%)

43 (20.4%)

3 (3.0%) **

34 (52.3%) **

6 (12.8%)

Anemia, n (%)

8 (3.8%)

3 (3.0%)

5 (7.7%)

0 (0.0%)

Obesity, n (%)

69 (34.5%)

22 (24.2%) **

27 (42.2%)

20 (44.4%)

Lung cancer, n (%)

0 (%)

0 (%)

0 (%)

0 (%)

Non-lung cancers, n (%)

24 (11.4%)

9 (9.1%)

9 (13.8%)

6 (12.8%)

Depression, n (%)

18 (8.5%)

3 (3.0%) **

2 (3.1%)

13 (27.7%) **

Anxiety, n (%)

3 (1.4%)

0 (0.0%)

1 (1.5%)

2 (4.3%)

  1. Values are presented as n (%) or mean with standard deviation (SD) [11]. Results from one cluster differing significantly from the two other clusters in combination are marked with: * p < 0.05; ** p < 0.01