From: Clusters of comorbidities in fibrotic hypersensitivity pneumonitis
Comorbidity | Entire cohort (n = 211) | Cluster 1 (n = 99) | Cluster 2 (n = 65) | Cluster 3 (n = 47) |
---|---|---|---|---|
Total number of comorbidities (SD) | 2.7 (2.1) | 1.4 (1.3) ** | 4.2 (2.2) ** | 3.3 (1.4) * |
Airway obstruction, n (%) | 20 (9.5%) | 11 (11.1%) | 3 (4.6%) | 6 (12.8%) |
Obstructive sleep apnea, n (%) | 19 (9.0%) | 6 (6.1%) | 9 (13.8%) | 4 (8.5%) |
Thromboembolic disorders, n (%) | 10 (4.7%) | 4 (4.0%) | 2 (3.1%) | 4 (8.5%) |
Pulmonary hypertension, n (%) | 20 (9.5%) | 0 (0.0%) ** | 18 (27.7%) ** | 2 (4.3%) |
Arterial hypertension, n (%) | 117 (55.5%) | 36 (36.4%) ** | 53 (81.5%) ** | 28 (59.6%) |
Ischemic heart disease, n (%) | 37 (17.5%) | 1 (1.0%) ** | 35 (53.8%) ** | 1 (2.1%) ** |
Atrial fibrillation, n (%) | 18 (8.5%) | 5 (5.1%) | 12 (18.5%) ** | 1 (2.1%) |
Other arrythmias, n (%) | 5 (2.4%) | 1 (1.0%) | 3 (4.6%) | 1 (2.1%) |
Heart failure, n (%) | 25 (11.9%) | 3 (3.0%) ** | 21 (32.3%) ** | 1 (2.1%) * |
Heart valve disease, n (%) | 8 (3.8%) | 2 (2.0%) | 6 (9.2%) * | 0 (0.0%) |
Cerebrovascular disease, n (%) | 19 (9.0%) | 4 (4.0%) * | 12 (18.5%) ** | 3 (6.4%) |
Peripheral artery disease, n (%) | 8 (3.8%) | 1 (1.0%) | 4 (6.2%) | 3 (6.4%) |
Vascular disease, n (%) | 2 (1.0%) | 0 (0.0%) | 2 (3.1%) | 0 (0.0%) |
Renal insufficiency, n (%) | 7 (3.3%) | 2 (2.0%) | 5 (7.7%) * | 0 (0.0%) |
Gastro-esophageal reflux disease, n (%) | 50 (23.7%) | 26 (26.3%) | 10 (15.4%) | 14 (29.8%) |
Liver disease, n (%) | 9 (4.3%) | 4 (4.0%) | 4 (6.2%) | 1 (2.1%) |
Hypothyroidism, n (%) | 28 (13.3%) | 0 (0.0%) ** | 5 (7.7%) | 23 (48.9%) ** |
Osteoporosis, n (%) | 26 (12.3%) | 0 (0.0%) ** | 4 (6.2%) | 22 (46.8%) ** |
Diabetes mellitus, n (%) | 43 (20.4%) | 3 (3.0%) ** | 34 (52.3%) ** | 6 (12.8%) |
Anemia, n (%) | 8 (3.8%) | 3 (3.0%) | 5 (7.7%) | 0 (0.0%) |
Obesity, n (%) | 69 (34.5%) | 22 (24.2%) ** | 27 (42.2%) | 20 (44.4%) |
Lung cancer, n (%) | 0 (%) | 0 (%) | 0 (%) | 0 (%) |
Non-lung cancers, n (%) | 24 (11.4%) | 9 (9.1%) | 9 (13.8%) | 6 (12.8%) |
Depression, n (%) | 18 (8.5%) | 3 (3.0%) ** | 2 (3.1%) | 13 (27.7%) ** |
Anxiety, n (%) | 3 (1.4%) | 0 (0.0%) | 1 (1.5%) | 2 (4.3%) |