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Table 1 Baseline characteristics of the entire cohort and the three clusters

From: Clusters of comorbidities in fibrotic hypersensitivity pneumonitis

Clinical characteristics

Entire cohort

(n = 211)

Cluster 1

(n = 99)

Cluster 2

(n = 65)

Cluster 3

(n = 47)

Male, n (%)

113 (53.6%)

57 (57.6%)

46 (70.8%) **

10 (21.3%) **

Age at diagnosis, years (SD)

63.0 (13.3)

59.3 (14.3) **

69.8 (10.2) **

61.3 (11.4)

Smoking status, n (%)

 

 Never

106 (50.2%)

47 (48.0%)

32 (49.2%)

27 (57.4%)

 Former

95 (45.2%)

45 (45.9%)

32 (49.2%)

18 (38.3%)

 Current

9 (4.3%)

6 (6.1%)

1 (1.5%)

2 (4.3%)

Pack years (IQR)

0 (0–20)

2 (0–20)

0 (0–30)

0 (0–10)

FVC, % predicted (SD)

72.7 (21.2)

72.9 (18.2)

74.0 (25.8)

70.3 (20.5)

TLC, % predicted (SD)

74.1 (15.9)

76.7 (14.6) *

71.3 (17.7)

72.6 (15.4)

DLCO, % predicted (SD)

44.1 (13.9)

46.3 (13.4)*

42.6 (14.9)

41.2 (13.2)

6MWD, m (SD)

373.4 (112.1)

402.0 (102.4)**

354.8 (109.0)

334.8 (122.8)*

Long-term oxygen therapy, n (%)

39 (18.5%)

12 (12.1%)*

18 (27.7%)*

9 (19.1%)

Lymphocytes in BAL, % of total (IQR)

24% (10–56%)

30% (14–61%)*

23% (6–48%)

21% (8–57%)

Biopsy (transbronchial cryobiopsi or surgical lung biopsy), n (%)

83 (39.3%)

45 (45.5%)

17 (26.2%)*

21 (44.7%)

ILD-GAP index, n (%)

 

0–1

96 (45.5%)

57 (57.6%)

*

15 (23.4%)

**

24 (54.5%)

2–3

87 (41.2%)

34 (34.3%)

37 (57.8%)

16 (36.4%)

4–5

19 (9.0%)

6 (6.1%)

9 (14.1%)

4 (9.1%)

 > 5

5 (2.4%)

2 (2.0%)

3 (4.7%)

0 (0.0%)

  1. Values are presented as n (%), mean with standard deviation (SD) or median with interquartile range (IQR) [11]. Results from one cluster differing significantly from the two other clusters in combination are marked with: *p < 0.05; **p < 0.01
  2. FVC forced vital capacity, TLC total lung capacity, DLCO diffusing capacity of the lung for carbon monoxide, 6MWD 6-min walk test distance, ILD Interstitial lung disease, GAP gender, age and physiology index, BAL bronchoalveolar lavage, HRCT high-resolution computed tomography