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Table 3 Protease profile (tryptase, chymase) and secretory activity of mast cells in the affected lung tissues

From: Role of mast cells in the pathogenesis of severe lung damage in COVID-19 patients

Parameter

COVID-19 group (n = 30)

Control group (n = 9)

p-value

Tryptase-positive MCs

 Non-Degranulated MCs

3.59 (2.36; 7.35)

2.00 (1.78; 2.44)

0.005

 Degranulated MCs

22.46 (17.47; 36.89)

19.78 (15.78; 26.22)

0.309

 Single MCs

23.34 (18.12; 37.78)

18.22 (16.89; 22.00)

0.167

 Collaborative Diligence

1.97 (1.33; 3.28)

1.33 (0.89; 1.78)

0.029

 Total

35.78 (24.0; 50.22)

28.00 (24.00; 35.11)

0.505

Chymase-positive MCs

 Non-Degranulated MCs

0.22 (0.00; 0.67)

1.11 (0.89; 1.11)

0.004

 Degranulated MCs

9.07 (3.56; 13.33)

4.44 (2.00; 5.33)

0.039

 Single MCs

7.95 (3.78; 12.74)

4.44 (3.11; 5.56)

0.161

 Collaborative diligence

0.89 (0.00; 1.78)

0.00 (0.00; 0.44)

0.009

 Total

15.53 (6.67; 25.87)

5.56 (3.56; 6.44)

0.014

  1. Data are presented as median (the upper and lower quartiles). MCs mast cells