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Table 3 Factors associated with ≥ 5% weight loss within the first year of IPF

From: Association between weight loss and mortality in idiopathic pulmonary fibrosis

 

OR

CI

p value

Univariate analysis

   

 ≥ 200 mL loss of FVC

3.03

[0.985, 9.341]

0.053

 Antifibrotic use

1.907

[0.673, 5.405]

0.22

 ARB use

3.071

[0.917, 10.28]

0.07

 ACE use

0.307

[0.035, 2.67]

0.28

 Pulmonary Rehab

1.467

[0.413, 4.902]

0.57

 Smoking

1.071

[0.386, 5.577]

0.90

 GERD

1.65

[0.565, 4.433]

0.34

 PPI

0.80

[0.286, 2.21]

0.66

 COPD

0.228

[0.027, 1.924]

0.17

 Diabetes

1.641

[0.467, 5.767]

0.30

 Pulmonary hypertension

1.211

[0.552, 6.99]

0.83

 Sleep apnea

0.647

[0.123, 3.407]

0.61

 Atrial fibrillation

0.480

[0.094, 2.437]

0.38

 Oxygen use

5.333

[1.762, 16.15]

0.003*

 Gender

1.286

[0.429, 3.852]

0.65

Multivariable analysis

   

 Oxygen use

13.167

[3.059–56.68]

0.0005*

 ≥ 200 mL loss of FVC

5.44

[1.28, 22.98]

.021*

 Age

1.034

[0.96, 1.114]

0.38

  1. ARB: angiotensin receptor blocker; ACE: Angiotensin converting enzyme inhibitor; BMI: body mass index; COPD: chronic obstructive lung disease; DLCO: diffusion limitation for carbon monoxide; FVC: forced vital capacity; GERD: gastroesophageal reflux; OSA: obstructive sleep apnea; PPI: proton pump inhibitor. *p value < 0.05