Table 1 Demographic and clinical characteristics of patients included in the EARCO registry and comparison between augmented and non-augmented PI*ZZ patients
Variables | All ZZ (n = 629) | ZZ non-augmented (n = 436) | ZZ augmented (n = 190) | p value |
|---|---|---|---|---|
Age, years | 55.6 (13.2) | 54.4 (14.0) | 58.4 (10.9) | 0.009 |
Sex, male (%) | 324 (51.5) | 208 (47.7) | 114 (60) | 0.005 |
BMI (kg/m2) | 26 (4.8) | 26 (4.8) | 26.1 (4.8) | 0.629 |
Smokers (%) | 11 (1.8) | 10 (2.3) | 1 (0.5) | 0.187 |
Ex-smokers (%) | 356 (56.8) | 202 (46.3) | 152 (80.9) | < 0.001 |
Never smokers (%) | 260 (41.5) | 224 (51.4) | 35 (18.6) | < 0.001 |
Tobacco Exposure (Pack-years) | 17.8 (14) | 14.2 (12.2) | 22.7 (14.8) | < 0.001 |
Working status | ||||
Active | 338 (53.8) | 263 (60.5) | 72 (37.9) | < 0.001 |
Retired | 235 (37.4) | 135 (31) | 100 (52.6) | < 0.001 |
Unemployed | 30 (4.8) | 15 (3.4) | 15 (7.9) | 0.029 |
Other | 25 (4.0) | 22 (5.1) | 3 (1.6) | 0.069 |
Age at diagnosis of AATD | 44.7 (16.7) | 43.1 (17.9) | 48.3 (13.0) | 0.010 |
Reason for diagnosis | ||||
Index case (%) | 457 (72.8) | 302 (69.4) | 152 (80.0) | 0.006 |
Family screening (%) | 115 (18.3) | 100 (22.9) | 15 (7.9) | < 0.001 |
Clinical characteristics | ||||
Chronic respiratory disease (%) | 508 (81.4) | 317 (73.5) | 188 (98.9) | < 0.001 |
COPD (%) | 349 (55.9) | 180 (41.8) | 167 (87.9) | < 0.001 |
Emphysema (%) | 357 (57.2) | 187 (43.4) | 169 (88.9) | < 0.001 |
Bronchiectasis (%) | 137 (22) | 87 (20.2) | 49 (25.8) | 0.120 |
Asthma (%) | 88 (14.1) | 74 (17.2) | 14 (7.4) | 0.001 |
Liver disease (%) | 99 (16) | 69 (16.1) | 30 (16) | 0.981 |
Charlson index (age corrected) | 3.3 (1.9) | 3 (1.9) | 4 (1.8) | < 0.001 |
Cardiovascular disease (%) | 163 (26.1) | 91 (20.9) | 72 (38.5) | < 0.001 |
Exacerbations previous year (%) | 189 (30.2) | 113 (25.9) | 75 (39.7) | < 0.001 |
History of pneumonia (%) | 173 (29.3) | 113 (28) | 57 (30.8) | 0.491 |