Nebulization of risedronate alleviates airway obstruction and inflammation of chronic obstructive pulmonary diseases via suppressing prenylation-dependent RAS/ERK/NF-κB and RhoA/ROCK1/MLCP signaling

Table 1 Absorption of risedronate aerosol in lung tissues of rats

Rats	Lung tissues	Weight (g)	Volume (ml)	Ris con (μg/ml)	Total inhaled (mg)	Absorbed (%)
	1	0.193	0.5	51.6	0.026	8.0
	2	0.260	0.5	130.5	0.065	20.0
No.1	3	0.318	0.5	169.2	0.085	26.2
	4	0.280	0.5	124.8	0.062	19.1
	5	0.211	0.5	65.4	0.033	10.2
	Total	1.262			0.271	83.50
	1	0.242	0.5	99.1	0.050	15.4
	2	0.264	0.5	118.5	0.059	18.2
No.2	3	0.302	0.5	139.2	0.070	21.5
	4	0.356	0.5	144.2	0.072	22.2
	5	0.265	0.5	107.3	0.054	16.6
	Total	1.429			0.305	93.9
	1	0.186	0.5	75.4	0.038	11.7
	2	0.262	0.5	124.5	0.062	19.1
Mean	3	0.310	0.5	154.2	0.078	23.9
	4	0.318	0.5	134.5	0.066	20.7
	5	0.238	0.5	86.4	0.044	13.4
	Total	1.346			0.288	88.8

ISSN: 1465-993X