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Fig. 5 | Respiratory Research

Fig. 5

From: Nebulization of risedronate alleviates airway obstruction and inflammation of chronic obstructive pulmonary diseases via suppressing prenylation-dependent RAS/ERK/NF-κB and RhoA/ROCK1/MLCP signaling

Fig. 5

The molecular diagram of the efficiency of risedronate on COPD. Risedronate could inhibite FDPS and then disrupte the RAS and RhoA prenylation to impede its membrane binding, ultimately resulting in inactivation of RAS-ERK-MLCK-pMLC20 and RhoA-ROCK1-MLCP-MLC20 singaling pathway. Decreased pMLC20 expanded the airway by relaxating ASMCs. Decreased ERK1/2 could directely or indriectly inhibite NF-κB pathway, leading to the inhibition of inflammation response and the infiltration of lymphocytes, neutrophils and macrophages

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