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Fig. 2 | Respiratory Research

Fig. 2

From: Nebulization of risedronate alleviates airway obstruction and inflammation of chronic obstructive pulmonary diseases via suppressing prenylation-dependent RAS/ERK/NF-κB and RhoA/ROCK1/MLCP signaling

Fig. 2

Risedronate attenuated the airway obstruction. A The Hematoxylin and Eosin (H&E) staining of the pulmonary section from COPD- rats (left) and those that received risedronate inhalation treatment (right). The histogram representing the differences of the two groups in the MLI. Scale bar, 50 µM. B The change in sRAW in COPD rats treated with different concentrations of risedronate (left) and those treated with 100 µM risedronate at different times (right). C The change in PEF, EF50, TV, and PIF (from left to right) in COPD rats treated with different concentrations of risedronate (0, 0.31, 0.625, 1.25, 2.5, 5 mg/ml). D The Hematoxylin and Eosin(H&E) staining of a pulmonary section in COPD mice (left) and those that received risedronate treatment (right). The histogram compares the two groups in the MLI. Scale bar, 50 µM. E The change in RI and Cdyn in COPD mice treated with different concentrations of risedronate (0, 0.31, 0.625, 1.25, 2.5, 5 mg/ml). F We tested the change in TV, PEF, MV, and PIF (from left to right) in COPD mice treated with different concentrations of risedronate (0,0.31, 0.625, 1.25, 2.5, 5 mg/ml)

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Respiratory Research

ISSN: 1465-993X

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