Blood Krebs von den Lungen-6 levels predict treatment response to antifibrotic therapy in patients with idiopathic pulmonary fibrosis

Table 2 Logistic regression analysis for DP in patients with IPF

Variables	Unadjusted			Multivariable (adjusted by age and FVC)
Variables	Odds ratio	95% CI	P-value	Odds ratio	95% CI	P-value
Age	1.057	1.007–1.109	0.026	–	–	–
Male sex	0.935	0.416–2.099	0.870	–	–	–
Ever-smoker	0.857	0.390–1.884	0.701	–	–	–
BMI, kg/m²	0.849	0.759–0.951	0.005	0.870	0.777–0.975	0.017
FVC, % predicted	0.973	0.952–0.995	0.015	–	–	–
DLco, % predicted	0.995	0.975–1.015	0.599	–	–	–
TLC, % predicted	0.979	0.947–1.011	0.196	–	–	–
6MWT, distance, m	0.994	0.991–0.998	0.001	0.996	0.992–1.000	0.035
6MWT, SpO2, %	0.971	0.918–1.027	0.308	–	–	–
Baseline KL-6, U/mL	1.000	1.000–1.001	0.104	–	–	–
Δ KL-6 (absolute), U/mL	1.003	1.000–1.006	0.039	1.002	0.999–1.005	0.111
Δ KL-6 (relative), %	1.029	0.997–1.063	0.077	1.028	0.993–1.064	0.120

DP: disease progression; CI: confidence interval; BMI: body mass index; FVC: forced vital capacity; DLco: diffusing capacity of the lung for carbon monoxide; TLC: total lung capacity; 6MWT: 6-minute walk test; KL-6: Krebs von den Lungen-6; and Δ: changes from baseline for 1 month

ISSN: 1465-993X