Plasma markers of COVID-19 severity: a pilot study

Respiratory Research

Table 4 Pearson’s correlation of APP plasma levels in patients with COVID-19 disease (n = 20)

Protein	ACT	SAA	AGP	HP	AAT	hs-CRP	A2MG	CP	ALB
ACT	1	0.77***	− 0.19	− 0.47	− 0.16	− 0.20	0.23	0.12	0.45
SAA	0.77***	1	− 0.20	− 0.33	0.04	− 0.02	0.02	0.27	0.04
AGP	− 0.19	− 0.20	1	0.61**	0.67**	0.63**	0.03	0.49	− 0.41
HP	− 0.47	− 0.33	0.61**	1	0.52	0.57	− 0.26	0.20	− 0.51
AAT	− 0.16	0.04	0.67**	0.52	1	0.70***	− 0.13	0.72***	− 0.58
Hs-CRP	− 0.20	− 0.02	0.63**	0.57	0.70***	1	− 0.23	0.42	− 0.50
A2MG	0.23	0.02	0.03	− 0.26	− 013	− 0.23	1	0.17	0.49
CP	0.12	0.27	0.49	0.20	0.72***	0.42	0.17	1	− 0.31
ALB	0.45	0.04	− 0.41	− 0.51	− 0.58	− 0.50	0.49	− 0.31	1

A2MG alpha2-macroglobulin, AAT alpha1-antitrypsin, ACT alpha 1-antichymo-trypsin, AGP alpha-1 acid glycoprotein, ALB albumin, CP ceruloplasmin, hs-CRP high sensitivity C-reactive protein, HP haptoglobin, SAA serum amyloid A. Two-sided p-value < 0.05, two stars (**) indicate a two-sided p-value < 0.01, three stars (***) indicate a two-sided p-value < 0.001. A p-value < 0.05 is considered as significant

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