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Table 1 Baseline characteristics in patients with IPAH and healthy controls

From: CircGSAP alleviates pulmonary microvascular endothelial cells dysfunction in pulmonary hypertension via regulating miR-27a-3p/BMPR2 axis

Characteristic

IPAH patients (n = 41)

Control subjects (n = 50)

Age, years

46.1 ± 17.6

48.3 ± 14.3

Male/Female, n

14/27

20/30

Nonsurvivors, n

12

0

BMI, kg/m2

22.8 ± 4.4

–

NT-proBNP, pg/mL

797 (296–3035)

–

WHO-FC III/IV, n (%)

25 (59.2)

–

6MWD, m

362.2 ± 109.7

–

mRAP, mmHg

6.0 ± 5.1

–

mPAP, mmHg

56.2 ± 18.6

–

mPAWP, mmHg

8.3 ± 4.0

–

PVR, Wood units

15.8 ± 13.5

–

CO, L/min

3.5 ± 1.4

–

Specific therapy, n (%)

  

PDE-5 inhibitors

10 (24.4)

–

ERAs

10 (24.4)

–

sGC stimulator

2 (4.9)

–

Combination

19 (46.3)

–

  1. 6MWD 6-minute walk distance, BMI body mass index, CO cardiac output, ERA endothelin receptor antagonist, IPAH idiopathic pulmonary arterial hypertension, mPAP mean pulmonary arterial pressure, mPAWP mean pulmonary capillary wedge pressure, mRAP mean right atrial pressure, NT-proBNP N-terminal pro-brain natriuretic peptide, PDE-5 phosphodiesterase type 5, PVR pulmonary vascular resistance, sGC soluble guanylate cyclase, WHO-FC World Health Organization Functional Class