Fig. 2

Effects of circGSAP on the progression of MCT-induced PH in rats. A Flow chart of the animal experiment. B Kaplan–Meier survival analysis for MCT-induced PH rats (n = 17). C, D RHC analysis of RVSP and the Fulton index in the control, MCT, MCT-AAV-NC and MCT-AAV groups (n = 11 or 8). E, F GFP fluorescent signals in the pulmonary arterial intima and the expression of circGSAP in MCT-AAV lung tissues (n = 4). G, H Echocardiography analysis of the RVEDD and PAT in the control, MCT, MCT-AAV-NC and MCT-AAV groups (n = 4). I–K Morphological analysis of the pulmonary artery was performed using α-SMA, HE and Masson staining (n = 4 or 10). All data are presented as the mean ± SEM. Scale bar: 100 μm