Analysis of sputum microbial metagenome in COPD based on exacerbation frequency and lung function: a case control study

Table 1 Clinical characteristics of the study population

	All	NFE	FE	p value	Severe	Mild	p value
N	39	19	20		19	20
Gender, Male (%)	29 (70.7%)	13 (68.4%)	16 (80%)	0.408	15 (78.9%)	14 (70%)	0.716
Age (years)
Range	56–88	60–84	56–88		56–88	60–84
Mean ± sd	69.18 ± 7.25	68.68 ± 6.84	69.65 ± 7.77	0.683	66 (61, 72)	70 (67, 74.75)	0.118
BMI
Range	15.43–32.28	16.60–32.28	15.43–29.38		15.43–30.19	16.60–32.28
Mean ± sd	23.74 ± 4.13	25.14 ± 4.03	22.41 ± 3.86	0.038	22.36 ± 4.23	25.05 ± 3.66	0.041
Smoking history
Ever-smoker	27(69.2%)	12(63.2%)	15(75%)		14(73.7%)	13(65%)
Never-smoker	12(30.8%)	7(36.8%)	5(25%)	0.423	5(26.3%)	7(35%)	0.557
FEV₁/pre (%)
Range	20.3–97.7	21.8–97.7	20.3–93.7		20.3–47.6	50.4–97.7
Mean ± sd	49.62 ± 20.91	58.6(39.2, 69.4)	37.55(25.4, 54.7)	0.009	32.1(23.1, 39.2)	64(56.13, 70.88)	< 0.001
FEV₁/FVC (%)
Range	25.67–68.76	25.67–68.76	27.03–68.24		25.67–61.48	46.71–68.76
Mean ± sd	48.36 ± 12.25	51.28 ± 11.94	45.59 ± 12.17	0.149	39.60 ± 10.08	56.69 ± 7.35	< 0.001

FE frequent exacerbators, NFE non-frequent exacerbators, sd standard deviation, N number, BMI body mass index, FEV₁ forced expiratory volume in 1 s, FEV₁/pre FEV₁ percent predicted, FVC forced vital capacity. Non-normal distributed data were expressed as medians and interquartile ranges (IQR)

ISSN: 1465-993X