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Table 2 Univariate and multivariate logistic regression analysis

From: Derivation and external validation of a simple prediction rule for the development of respiratory failure in hospitalized patients with influenza

VARIABLE

Univariate OR (CI 95%)

p

Multivariate OR (CI 95%)

p

FM OR (CI 95%)

p

Age*

0.980 (0.964–0.997)

0.023

0.977 (0.955–0.999)

0.037

  

Sex (male)

1.339 (0.744–2.410)

0.331

    

Influenza vaccine

0.623 (0.338–1.148)

0.129

    

Hypertension

0.753 (0.410–1.381)

0.359

    

Current smokers

1.624 (0.759–3.475)

0.212

    

Obesity

0.610 (0.254–1.467)

0.270

    

COPD

1.783 (0.961–3.309)

0.067

1.980 (0.954–4.109)

0.067

  

Diabetes mellitus

0.622 (0.304–1.272)

0.193

    

Immunossupresion

0.604 (0.251–1.453)

0.260

0.671 (0.265–1.704)

0.671

  

CCI

1.030 (0.922–1.151)

0.599

    

Respiratory rate*

1.114 (1.090–1.200)

< 0.001

1.112 (1.055–1.172)

< 0.001

1.110 (1.056–1.168)

0.000

SpO2 on room air*

0.927 (0.895–0.960)

< 0.001

    

Radiological abnormalities

2.093 (1.149–3.814)

0.016

2.826 (1.333–5.991)

0.007

2.715 (1.341–5.498)

0.006

Secondary pneumonia

3.067 (1.663–5.657)

< 0.001

    

Platelets (cells/µl)*

1.002 (0.999–1.005)

0.224

    

Lymphocytes (cells/µl)*

1.008 (0.995–1.021)

0.217

1.000 (1.000–1.000)

0.070

1.000 (1.000–1.000)

0.094

CRP (mg/dl)*

1.020 (0.992–1.049)

0.160

1.002 (0.968–1.037)

0.929

  

LDH (U/l)*

1.004 (1.002–1.005)

< 0.001

1.003 (1.001–1.005)

0.002

1.003 (1.002–1.005)

0.000

  1. OR odds ratio, CI confidence interval, FM final multivariate model after backwards elimination, COPD chronic obstructive pulmonary disease, CCI Charlson Comorbidity Index, SpO2 oxygen saturation, CRP C-reactive protein, LDH lactate dehydrogenase. *Odds Ratio per increment of 1 unit