Table 2 Clinical significance of miRNA up-/downregulation in humans with ARDS
References | Micro-RNA | Model | Effect | Clinical significance |
|---|---|---|---|---|
Lee et al. [123] | miR-106a-5p, miR-17-5p, miR-29a-3 | All-cause ARDS | Upregulated | Prediction of mortality |
miR-126-3p, miR-191-5p, miR-223-3p | Downregulated | |||
Wang et al. [116] | miR-103, miR-107 | Sepsis-associated ARDS | Downregulated | Increased risk of ARDS and 28-day mortality |
Xu et al. [117] | miR-92 | Sepsis-associated ARDS | Upregulated | Risk of ARDS |
Wang et al. [120] | miR155 | Sepsis-associated ARDS | Upregulated | Association with inflammatory lung injury |
Wu et al. [121] | miR-27a, miR-126, miR-146a, miR-155 | Pneumonia-associated ALI | Upregulated | Risk of ARDS |
Rahmel et al. [124] | miR-122 | All-cause ARDS | Upregulated | Association with acute liver injury and ARDS |
Li et al. [125] | miR-140 | ALI except sepsis | Downregulated | Association with ALI and inflammation |
Zhu et al. [126] | miR-181a, miR-92a | All-cause ARDS | Upregulated | Risk of ARDS |
miR-424 | Downregulated | |||
Goodwin et al. [122] | miR-887-3p | Sepsis-associated ARDS | Upregulated | Risk of ARDS |
Lu et al. [127] | miR-22-3p, 1260b, 762, 23b, 23a | AP-associated ARDS | Upregulation | Risk of pancreatitis and ARDS |
has-miR-550a, 324-5p, 484, 331-3p, 22-3p, 140-3p, 342-3p | Downregulated | |||
Shi et al. [118] | miR-127 | AP-associated ALI | Upregulated | Association with acute pancreatitis and ARDS |
| Â | miR-199a | Sepsis-associated ARDS | Downregulated | Risk of ARDS |
Zhu et al. [119] | miR-628-3p, miR-766, miR-922, miR-7, miR-194 | All-cause ARDS | Upregulated | Increased 28-day mortality |