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Table 2 Baseline characteristics of all included patients, stratified by the original COMPERA 2.0 4-stratum

From: The original and two new derivative versions of the COMPERA 2.0 risk assessment model: useful tools for guiding balloon pulmonary angioplasty

Variables

All (n = 175)

Low risk (n = 37)

Intermediate-low risk(n = 52)

Intermediate-high risk (n = 74)

High risk (n = 12)

P-value

Demographics

 Age, years

60.1 ± 10.8

54.2 ± 12.4

62.4 ± 9.4

61.2 ± 10.2

61.1 ± 10.1

0.003

 Body mass index, kg/m2

23.9 ± 3.4

25.5 ± 3.5

23.7 ± 2.9

23.7 ± 3.6

21.9 ± 2.3

0.005

 Female, n (%)

92 (52.6)

16 (43.2)

32 (61.5)

37 (50)

7 (58.3)

0.344

 Disease duration, years

3 (1, 7)

2 (1, 4)

3 (1, 6)

4.0 (2.0, 8.3)

4.5 (2.4, 7.3)

0.025

 WHO-FC

< 0.001

  I, n (%)

1 (0.6)

1 (2.7)

0

0

0

 

  II, n (%)

61 (34.9)

36 (97.3)

24 (46.2)

1 (1.4)

0

 

  III, n (%)

108 (61.7)

0

28 (53.8)

72 (97.3)

8 (66.7)

 

  IV, n (%)

5 (2.9)

0

0

1 (1.4)

4 (33.3)

 

 NT-proBNP, ng/L

759.9 (209.0, 1659.3)

106.6 (52.5, 223.6)

379.0 (178.0, 974.5)

1491.5 (823.5, 2671.3)

2502.0 (1831.3, 2738.0)

< 0.001

 6MWD, m

350.5 ± 110.6

451.7 ± 74.6

375.9 ± 88.6

312.3 ± 84.2

163.0 ± 78.3

< 0.001

 PH specific medicine

0.252

  None, n (%)

54 (30.9)

16 (43.2)

19 (36.5)

16 (21.6)

3 (25)

 

  Mono, n (%)

109 (62.3)

18 (48.6)

29 (55.8)

54 (73)

8 (66.7)

 

  Double, n (%)

12 (6.9)

3 (8.1)

4 (7.7)

4 (5.4)

1 (8.3)

 

Echocardiography

      

 RVED/LVED

0.84 ± 0.25

0.66 ± 0.13

0.73 ± 0.16

0.96 ± 0.26

1.06 ± 0.21

< 0.001

 EF, %

65.1 ± 6.2

65.9 ± 5.7

64.8 ± 5.5

64.7 ± 6.6

66.6 ± 8.1

0.664

 TRV, m/s

4.28 ± 0.68

3.84 ± 0.85

4.15 ± 0.63

4.53 ± 0.48

4.61 ± 0.63

< 0.001

Hemodynamics

      

 SvO2, %

66.8 ± 8.29

71.1 ± 4.7

68.7 ± 10.5

63.9 ± 6.7

62.54 ± 6.8

< 0.001

 mRAP, mmHg

8 (5, 9)

7.0 (4.5, 9.0)

7 (5, 8)

8 (6, 10)

11.5 (8.3, 17.0)

0.001

 mPAP, mmHg

49.4 ± 11.8

43.1 ± 9.9

45.3 ± 12.6

54.8 ± 9.5

53.2 ± 9.9

< 0.001

 PAWP, mmHg

10.4 ± 3.4

10.7 ± 1.6

10.0 ± 2.0

10.2 ± 2.4

11.9 ± 3.1

0.041

 CI, L/min/m2

2.86 ± 0.72

3.23 ± 0.53

2.89 ± 0.47

2.46 ± 0.54

2.36 ± 0.73

< 0.001

 PVR, wood units

10.4 ± 4.6

6.61 ± 2.75

8.74 ± 3.56

13.18 ± 4.09

12.81 ± 4.66

< 0.001

  1. Data are presented as mean ± standard deviation, median (interquartile range) or number (percentage)
  2. CI cardiac index, EF ejection fraction, LVED left ventricular end-diastolic diameter, mPAP mean pulmonary artery pressure, mRAP mean right atrial pressure, NT-proBNP N-terminal pro-brain natriuretic peptide, PAWP pulmonary artery wedge pressure, PVR pulmonary vascular resistance, RVED right ventricular end-diastolic diameter, 6MWD 6-min walk distance, SvO2 mixed venous oxygen saturation, TRV tricuspid regurgitation velocity, WHO-FC World Health Organization function class