Variables | All (n = 175) | Low risk (n = 37) | Intermediate-low risk(n = 52) | Intermediate-high risk (n = 74) | High risk (n = 12) | P-value |
---|---|---|---|---|---|---|
Demographics | ||||||
 Age, years | 60.1 ± 10.8 | 54.2 ± 12.4 | 62.4 ± 9.4 | 61.2 ± 10.2 | 61.1 ± 10.1 | 0.003 |
 Body mass index, kg/m2 | 23.9 ± 3.4 | 25.5 ± 3.5 | 23.7 ± 2.9 | 23.7 ± 3.6 | 21.9 ± 2.3 | 0.005 |
 Female, n (%) | 92 (52.6) | 16 (43.2) | 32 (61.5) | 37 (50) | 7 (58.3) | 0.344 |
 Disease duration, years | 3 (1, 7) | 2 (1, 4) | 3 (1, 6) | 4.0 (2.0, 8.3) | 4.5 (2.4, 7.3) | 0.025 |
 WHO-FC | < 0.001 | |||||
  I, n (%) | 1 (0.6) | 1 (2.7) | 0 | 0 | 0 |  |
  II, n (%) | 61 (34.9) | 36 (97.3) | 24 (46.2) | 1 (1.4) | 0 |  |
  III, n (%) | 108 (61.7) | 0 | 28 (53.8) | 72 (97.3) | 8 (66.7) |  |
  IV, n (%) | 5 (2.9) | 0 | 0 | 1 (1.4) | 4 (33.3) |  |
 NT-proBNP, ng/L | 759.9 (209.0, 1659.3) | 106.6 (52.5, 223.6) | 379.0 (178.0, 974.5) | 1491.5 (823.5, 2671.3) | 2502.0 (1831.3, 2738.0) | < 0.001 |
 6MWD, m | 350.5 ± 110.6 | 451.7 ± 74.6 | 375.9 ± 88.6 | 312.3 ± 84.2 | 163.0 ± 78.3 | < 0.001 |
 PH specific medicine | 0.252 | |||||
  None, n (%) | 54 (30.9) | 16 (43.2) | 19 (36.5) | 16 (21.6) | 3 (25) |  |
  Mono, n (%) | 109 (62.3) | 18 (48.6) | 29 (55.8) | 54 (73) | 8 (66.7) |  |
  Double, n (%) | 12 (6.9) | 3 (8.1) | 4 (7.7) | 4 (5.4) | 1 (8.3) |  |
Echocardiography | Â | Â | Â | Â | Â | Â |
 RVED/LVED | 0.84 ± 0.25 | 0.66 ± 0.13 | 0.73 ± 0.16 | 0.96 ± 0.26 | 1.06 ± 0.21 | < 0.001 |
 EF, % | 65.1 ± 6.2 | 65.9 ± 5.7 | 64.8 ± 5.5 | 64.7 ± 6.6 | 66.6 ± 8.1 | 0.664 |
 TRV, m/s | 4.28 ± 0.68 | 3.84 ± 0.85 | 4.15 ± 0.63 | 4.53 ± 0.48 | 4.61 ± 0.63 | < 0.001 |
Hemodynamics | Â | Â | Â | Â | Â | Â |
 SvO2, % | 66.8 ± 8.29 | 71.1 ± 4.7 | 68.7 ± 10.5 | 63.9 ± 6.7 | 62.54 ± 6.8 | < 0.001 |
 mRAP, mmHg | 8 (5, 9) | 7.0 (4.5, 9.0) | 7 (5, 8) | 8 (6, 10) | 11.5 (8.3, 17.0) | 0.001 |
 mPAP, mmHg | 49.4 ± 11.8 | 43.1 ± 9.9 | 45.3 ± 12.6 | 54.8 ± 9.5 | 53.2 ± 9.9 | < 0.001 |
 PAWP, mmHg | 10.4 ± 3.4 | 10.7 ± 1.6 | 10.0 ± 2.0 | 10.2 ± 2.4 | 11.9 ± 3.1 | 0.041 |
 CI, L/min/m2 | 2.86 ± 0.72 | 3.23 ± 0.53 | 2.89 ± 0.47 | 2.46 ± 0.54 | 2.36 ± 0.73 | < 0.001 |
 PVR, wood units | 10.4 ± 4.6 | 6.61 ± 2.75 | 8.74 ± 3.56 | 13.18 ± 4.09 | 12.81 ± 4.66 | < 0.001 |