Fig. 4

HNRNPC was involved in cell growth, cell migration, extracellular matrix organization and angiogenesis. a We constructed H1299 cells with stably knockdown of HNRNPC (shHNRNPC) and control cells (sh-NC). By RNA-seq analysis, 10,907 differentially expressed genes were identified, including 5653 upregulated and 5254 downregulated genes. b The GO analysis revealed that the differentially expressed genes were enriched in cell migration, angiogenesis, extracellular matrix organization, cell proliferation, T cell mediated cytotoxicity and collagen fibril organization. c–h The GSEA analysis demonstrated that the cell growth, cell migration, extracellular matrix organization, angiogenesis, collagen fibril organization and T cell mediated cytotoxicity were correlated with HNRNPC knockdown