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Fig. 3 | Respiratory Research

Fig. 3

From: HNRNPC, a predictor of prognosis and immunotherapy response based on bioinformatics analysis, is related to proliferation and invasion of NSCLC cells

Fig. 3

HNRNPC predicted poor prognosis in NSCLC patients and correlated with tumor invasion and lymph node metastasis. a, b The expression of HNRNPC was significantly increased in NSCLC tissues and HNRNPC was mainly localized to the nucleus (n = 30). c The relationship between HNRNPC and clinicopathological characteristics of NSCLC patients was analyzed. A correlation existed between higher HNRNPC expression and deeper tumor invasion, and a correlation between greater HNRNPC expression and an elevated probability of lymph node metastasis. d In UALCAN and GEPIA databases, the expression of HNRNPC was elevated in LUAD and LUSC tissues. e In LUAD and LUSC tissues of GEPIA database, further correlation analysis indicated a positive expression correlation between HNRNPC and PCNA, along with a positive expression correlation between HNRNPC and N-cadherin. f The survival analysis revealed that high HNRNPC expression in 30 tumor tissues predicted a poor prognosis for NSCLC patients. g In HPA database, the data also suggested that the NSCLC patients with high expression of HNRNPC had a shorter overall survival. h We collected 8 cases of NSCLC tissues and ANTs, and increased expression of HNRNPC was confirmed in NSCLC tissues (n = 8). i PCNA and N-cadherin were abundant in NSCLC tissues than ANTs. In NSCLC tissues, further correlation analysis also indicated a positive expression correlation between HNRNPC and PCNA, along with a positive expression correlation between HNRNPC and N-cadherin. *P < 0.05

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Respiratory Research

ISSN: 1465-993X

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