Fig. 7

Investigation of differences in tumor immune cell infiltration among the four UrCCG subtypes. A–C ESTIMATE (Estimation of Stromal and Immune cells in Malignant Tumor tissues using Expression data) (https://bioinformatics.mdanderson.org/estimate/disease.html)method was used to calculate the stromal score (A), immune score (B), and tumor purity (C) of single samples in the TCGA-LUAD cohort, which were compared among G1–G4 subtypes (Kruskal–Wallis test). D Heatmap of enrichment scores of 28 immune cell signatures in TCGA-LUAD cohort sorted by UrCCG subtypes. E. Comparison of the cellular composition of 28 immune infiltrates among G1-G4 subtypes. *p < 0.05, **p < 0.01, and ***p < 0.001