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Table 2 Association of environmental exposures with black carbon area and black carbon percent

From: Black carbon content in airway macrophages is associated with increased severe exacerbations and worse COPD morbidity in SPIROMICS

 

Predicted Change (95% CI) in

Black Carbon Area

Predicted Change (95% CI) in

Black Carbon Percent

 

Minimally Adjusted*

Fully Adjusted†

Minimally Adjusted*

Fully Adjusted†

Exposure

Indoor PM2.5

10.0%

(0.5%, 20.4%)

7.8%

(-1.0%, 17.3%)

13.1%

(3.5%, 23.6%)

10.7%

(1.6%, 20.6%)

Indoor NO2

3.5%

(-4.7%, 12.3%)

2.3%

(-4.5%, 9.5%)

3.4%

(-4.5%, 11.9%)

1.5%

(-4.5%, 7.9%)

Indoor Nicotine

4.4%

(-2.6%, 12.0%)

2.7%

(-2.8%, 8.6%)

5.0%

(-4.5%, 15.5%)

2.9%

(-5.1%, 11.6%)

Urinary Cotinine

11.1%

(3.1%, 19.7%)

9.7%

(-1.0%, 21.5%)

12.5%

(5.3%, 20.2%)

10.7%

(2.2%, 19.9%)

VGDF (yes/no)

-0.2%

(-10.8%, 11.7%)

-1.9%

(-12.8%, 10.4%)

2.9%

(-7.7%, 14.8%)

1.0%

(-9.5%, 12.7%)

Ambient PM2.5

1.4%

(-4.2%, 7.4%)

2.7%

(-3.0%, 8.6%)

-0.7%

(-3.3%, 2.1%)

-0.9%

(-4.4%, 2.7%)

Ambient NO2

1.5%

(-3.1%, 6.3%)

1.2%

(-3.4%, 6.0%)

-0.3%

(-4.4%, 4.0%)

-1.6%

(-6.4%, 3.4%)

Ambient Ozone

-0.08%

(-6.7%, 7.0%)

-0.3%

(-7.4%, 7.3%)

0.9%

(-3.0%, 4.9%)

1.7%

(-3.3%, 7.0%)

  1. The effect estimates represent the predicted change in log AM BC, expressed in percentage change in original unit scaling, per 1 SD rise in the level (ug/m3) of the environmental exposure
  2. *Adjusted for batch (first vs. second)
  3. †Adjusted for batch (first vs. second), age, race (white vs. non-white), income (<$35,000, $35,000~$74,999, ≥$75,000, decline to answer), BMI, and LABA/LAMA use (yes vs. no)
  4. As a sensitivity analysis, when adjusting for urinary cotinine in the fully adjusted model assessing indoor PM2.5 association with AM BC, a one SD greater indoor PM2.5 concentration showed a nominal association with AM BC (BC area: β = 4.39%, 95% CI: -4.44%, 14.3%, P = 0.335; BC percent: β = 7.71%, 95% CI: -0.34%, 16.4%, P = 0.061)