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Table 2 Pre-bronchodilator and post-bronchodilator spirometry parameters of participants by spirometric lung function class

From: Preserved ratio impaired spirometry is associated with small airway dysfunction and reduced total lung capacity

Characteristic

Healthy control

(n = 628)

PRISm

(n = 126)

Spirometry-defined COPD (n = 685)

Before bronchodilator use

   

FEV1, L

2.49 ± 0.53

1.82 ± 0.42*

1.85 ± 0.62

FEV1% of predicted, %

93.7 ± 11.2

70.7 ± 8.8*

68.6 ± 19.6

FVC, L

3.27 ± 0.72

2.44 ± 0.58*†

3.24 ± 0.80

FVC% of predicted, %

98.3 ± 12.0

75.2 ± 10.4*†

94.6 ± 18.7

FVC < 80%predicted, n (%)

38 (6.1)

89 (70.6)*†

153 (22.3)

FEV1/FVC, %

76.6 ± 6.3

74.9 ± 5.9†

56.4 ± 10.2

After bronchodilator use

   

FEV1, L

2.57 ± 0.52

1.85 ± 0.38*

1.97 ± 0.61

FEV1% of predicted, %

96.7 ± 10.5

72.2 ± 6.8*

72.9 ± 19.0

FVC, L

3.26 ± 0.70

2.40 ± 0.53*†

3.36 ± 0.78

FVC% of predicted, %

97.9 ± 11.2

74.0 ± 8.4*†

98.0 ± 17.7

FVC < 80% predicted, n (%)

24(3.8)

91(72.2)*†

102 (14.9)

FEV1/FVC, %

79.3 ± 5.6

77.6 ± 5.8†

58.0 ± 9.7

Airflow reversibility, n (%)

33 (5.3)

9 (7.1)†

122 (17.8)

  1. Data are mean ± standard deviation or n (%)
  2. Abbreviations: PRISm, preserved ratio impaired spirometry; COPD, chronic obstructive pulmonary disease; FEV1, forced expiratory volume in one second; FVC, forced vital capacity
  3. * P < 0.05 compared with healthy control adjusting for multiple comparisons using Bonferroni correction method
  4. † P < 0.05 compared with COPD adjusting for multiple comparisons using Bonferroni correction method