CC16 polymorphisms in asthma, asthma subtypes, and asthma control in adults from the Agricultural Lung Health Study

Table 3 Associations between CC16 polymorphisms and uncontrolled asthma and exacerbations in the ALHS (N = 1120)

	CC16 rs12270961					CC16 rs3741240
	Genotype n (row %)					Genotype n (row %)
Outcome	AA	AG	GG	Adj OR (95% CI)*	p	AA	AG	GG	Adj OR (95% CI)*	p
Asthma Control ^*					0.03					0.64
Controlled	22 (4.2)	189 (36.2)	311 (59.6)	Ref		70 (13.4)	230 (44.1)	222 (42.5)	Ref
Uncontrolled	8 (3.9)	58 (27.9)	142 (68.3)	1.4 (1.0, 1.9)		25 (12.0)	90 (43.3)	93 (44.7)	0.9 (0.7, 1.2)
Asthma exacerbation past 12 months ^†					0.40					0.16
No	41 (4.0)	335 (33.0)	639 (63.0)	Ref		125 (12.3)	451 (44.4)	439 (43.3)	Ref
Yes	2 (3.4)	16 (27.1)	41 (69.5)	1.2 (0.8,2.1)		4 (6.8)	25 (43.4)	30 (50.9)	0.7 (0.5, 1.1)

Additive genetic model for the rs12270961 genotype coded as the number of copies of the G allele; for the rs3741240 genotype, as the number of copies of the A allele; thus, ORs reflect a multiplicative change in odds per additional copy of the designated allele
*Asthma control: controlled < 1.5 score, uncontrolled ≥ 1.5 score. 730 adults with asthma had asthma control data. Multivariable logistic regression model was fit with 722 observations (8 subjects lost due to missing a value for atopy) and adjusted for age, gender, state (IA or NC), smoking status (never, former, current), and atopy
†Exacerbation defined as ‘Yes’ to at least one of two questions: “In the past 12 months did you get urgent treatment for an asthma attack at a doctor’s office, urgent care facility, or ER?” or “In the past 12 months have you been hospitalized overnight for asthma?”
Multivariable logistic regression model adjusted for age, gender, state (IA or NC), smoking status (never, former, current), and atopy

ISSN: 1465-993X