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Table 2 Associations of CC16 polymorphisms with asthma and asthma subtypes in the ALHS (N = 3046)

From: CC16 polymorphisms in asthma, asthma subtypes, and asthma control in adults from the Agricultural Lung Health Study

 

CC16 rs12270961

CC16 rs3741240

 

Genotype n (row %)

  

Genotype n (row %)

  

Outcome

AA

AG

GG

Adj OR

(95% CI)*

p

AA

AG

GG

Adj OR

(95% CI)*

p

Asthma

    

0.98

    

0.69

 No

77 (4.0)

639 (33.2)

1210 (62.8)

Ref

 

249 (12.9)

843 (43.8)

834 (43.3)

Ref

 

 Yes

44 (3.9)

370 (33.0)

706 (63.0)

1.0 (0.9,1.1)

 

133 (11.9)

501 (44.7)

486 (43.4)

1.0 (0.9,1.1)

 

Atopy/Asthma *

    

0.83

    

0.78

 Neither

63 (3.9)

541 (33.1)

1029 (63.0)

Ref

 

209 (12.8)

718 (44.0)

706 (43.2)

Ref

 

 Atopy only

14 (5.7)

75 (30.7)

155 (63.5)

1.0 (0.8,1.2)

 

33 (13.5)

100 (41.0)

111 (45.5)

1.0 (0.8,1.2)

 

 Asthma only

33 (4.2)

264 (33.2)

498 (62.6)

1.0 (0.8,1.1)

 

102 (12.8)

352 (44.3)

341 (42.9)

1.0 (0.9,1.1)

 

 Both

10 (3.3)

95 (31.8)

194 (64.9)

1.1 (0.9,1.3)

 

30 (10.0)

137 (45.8)

132 (44.2)

0.9 (0.8,1.1)

 

Eosinophilia/Asthma †

    

0.94

    

0.96

 Neither

69 (3.9)

587 (33.1)

1119 (63.0)

Ref

 

229 (12.9)

765 (43.1)

781 (44.0)

Ref

 

 Eosinophilia only

1 (3.6)

9 (32.1)

18 (64.3)

1.2 (0.6,2.5)

 

4 (14.3)

14 (50.0)

10 (35.7)

1.2 (0.7,2.0)

 

 Asthma only

39 (4.0)

319 (32.9)

613 (63.1)

1.0 (0.9,1.1)

 

117 (12.1)

438 (45.1)

416 (42.8)

1.0 (0.9,1.1)

 

 Both

3 (4.4)

23 (33.8)

42 (61.8)

0.9 (0.6,1.4)

 

11 (16.2)

26 (38.2)

31 (45.6)

1.0 (0.7,1.5)

 
  1. Additive genetic model for the rs12270961 genotype coded as the number of copies of the G allele; for the rs3741240 genotype, as the number of copies of the A allele; thus, ORs reflect a multiplicative change in odds per additional copy of the designated allele
  2. Multivariable logistic regression model to estimate Odds Ratios and 95% confidence intervals. Asthma model adjusted for gender, state (NC, IA), age, smoking status (current, former, never). Multinomial logistic regression model to estimate adjusted odds ratios and 95% confidence intervals for each asthma subtype outcome category compared to reference category per each additional allele. Adjusted for gender, state (NC, IA), age, smoking status (current, former, never). Models were not adjusted for race because sample population is 99.9% white
  3. *Atopy/asthma = atopy defined as 1 or more allergen-specific IgE ≥ 0.70 IU/mL cross-classified with self-reported asthma (yes/no) resulting in four groups
  4. †Eosinophilia/asthma = eosinophilic defined by fractional exhaled nitric oxide (FeNo) > 50 ppb cross-classified with self-reported asthma (yes/no) resulting in four groups