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Table 1 Characteristics of the Agricultural Lung Health Study Population

From: CC16 polymorphisms in asthma, asthma subtypes, and asthma control in adults from the Agricultural Lung Health Study

 

Total

n = 3046

Asthma

n = 1120

No Asthma

n = 1926

Age, mean (SD)

62.6 (11.1)

61.8 (10.8)

63.1 (11.2)

Gender, n (%)

   

 Male

1566 (51.4)

528 (47.1)

888 (46.1)

 Female

1480 (48.6)

592 (52.9)

1038 (53.9)

BMI kg/m2, mean (SD)

30.15 (6.1)

31.32 (6.7)

29.50 (5.6)

 Missing

40 (1.3)

18 (1.6)

22 (1.1)

State, n (%)

   

 Iowa

2179 (71.5)

805 (71.9)

1374 (71.3)

 North Carolina

867 (28.5)

315 (28.1)

552 (28.7)

Race, n (%)

   

 White

3043 (99.9)

1120 (100.0)

1923 (99.8)

 Other

3 (0.1)

0 (0.0)

3 (0.2)

Smoking status, n (%)

   

 Never

1982 (65.1)

765 (68.3)

1217 (63.2)

 Former

890 (29.2)

308 (27.5)

582 (30.2)

 Current

126 (4.1)

32 (2.9)

94 (4.9)

 Missing

48 (1.6)

15 (1.3)

33 (1.7)

Pack-years*, median (IQR)

9.0 (25.5)

6.5 (18.5)

11.3 (28.5)

 Missing

4 (0.1)

3 (0.3)

1 (0.03)

Currently Farming†, n (%)

1908 (62.6)

688 (61.4)

1220 (63.3)

 Missing

1 (0.03)

1 (0.03)

0 (0.0)

Family history of asthma, n (%)

807 (26.5)

449 (40.1)

358 (18.6)

 Missing

34 (1.1)

16 (1.4)

18 (0.9)

Atopy‡, n (%)

   

 Yes

543 (17.8)

299 (26.7)

244 (12.7)

 No

2428 (79.7)

795 (71.0)

1633 (84.8)

 Missing

75 (2.5)

26 (2.3)

49 (2.5)

FeNO§, n (%)

   

 ≤ 50 ppb

2746 (90.2)

971 (86.7)

1775 (92.2)

 >50 ppb

96 (3.2)

68 (6.1)

28 (1.5)

 Missing

204 (6.7)

81 (7.2)

123 (6.4)

Asthma Control among diagnosed asthmatics||, n (%)

   

 Controlled

 

522 (46.6)

-

 Uncontrolled

 

208 (18.6)

-

 Missing

 

390 (34.8)

-

Exacerbations past 12 months, n (%)

   

 Yes

 

59 (5.3)

-

 No

 

1015 (90.6)

-

 Missing

 

46 (4.1)

-

rs3741240

   

 AA

382 (12.5)

133 (11.9)

249 (12.9)

 AG

1344 (44.1)

501 (44.7)

843 (43.8)

 GG

1320 (43.3)

486 (43.4)

834 (43.3)

 HWE p-value

0.17

0.82

0.12

rs4963506

   

 AA

119 (3.9)

43 (3.8)

76 (4.0)

 AG

999 (32.8)

367 (32.8)

632 (32.8)

 GG

1928 (63.3)

710 (63.4)

1218 (63.2)

 HWE p-value

0.46

0.60

0.59

rs12270961

   

 AA

121 (4.0)

44 (3.9)

77 (4.0)

 AG

1009 (33.1)

370 (33.0)

639 (33.2)

 GG

1916 (62.9)

706 (63.0)

1210 (62.8)

 HWE p-value

0.41

0.60

0.52

  1. Definition of abbreviation: HWE = Hardy-Weinberg Equilibrium
  2. *Pack-years among former or current smokers
  3. †Currently farming defined as during the past 12 months spent time growing, harvesting crops or any farm work related to growing or harvesting soybeans, wheat, corn, hay, straw, tobacco, cotton or other crops and/or worked with farm animals
  4. ‡Atopy defined as allergen-specific IgE to at least one of 10 allergens using a threshold of ≥ 0.70 IU/ml. Seasonal: Bermuda grass, ragweed, timothy grass, mountain cedar; Perennial: Alternaria, dust mite, cat dander; Food: milk, egg, and wheat
  5. §Fractional exhaled nitric oxide (FeNO) > 50 ppb used to define eosinophilic asthma subtype, ≤ 50 ppb used to define non-eosinophilic asthma subtype
  6. ││Asthma control: controlled < 1.5 score, uncontrolled ≥ 1.5 score in people with diagnosed current asthma or ACO (n = 829). The majority of adults identified as undiagnosed asthma did not receive questions about asthma control
  7. ¶Exacerbation defined as ‘Yes’ to at least one of two questions “In the past 12 months did you get urgent treatment for an asthma attack at a doctor’s office, urgent care facility, or ER?” or “In the past 12 months have you been hospitalized overnight for asthma?” among people with asthma
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Respiratory Research

ISSN: 1465-993X

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