Table 1 Characteristics of subjects enrolled in the quantification of IL-10 producing B-regs in PBMCs (n = 30)
From: IL-10 producing regulatory B cells are decreased in blood from smokers and COPD patients
Healthy | Smoker | COPD | |
|---|---|---|---|
Subjects | N = 9 | N = 8 | N = 13 |
Age (years) | 57.22 (6.18) | 62.63 (7.44) | 63.54 (6.79) |
Male sex (%) | 2 (22.22) | 3 (37.5) | 6 (46.2) |
BMI | 26.11 (5.78) | 27.02 (3.31) | 25.82 (5.82) |
Smoking | |||
Ex (%) | NA | 4 (50) | 10 (76.9) |
Current (%) | NA | 4 (50) | 3 (23.1) |
Pack-years | 0 (0–0) | 24,5+ (12.80–36,20) | 36.12+ (28.42–43.80) |
Lung function | |||
FEV1 pre (% predicted) | 108 (97–118) | 106 (95–118) | 46+ϒ (32–61) |
FEV1 post (% predicted) | NA | NA | 44 (31–56) |
FVC pre (% predicted) | 112 (102–123) | 109 (96–121) | 82 (71–94) |
FEV1/FVC pre (%) | 77 (74–79) | 78 (75–81) | 43+ϒ (33–53) |
FEV1/FVC post (%) | NA | NA | 41 (31–51) |
CAT test score total | 8.22 (2.81) | 8.75 (5.75) | 19.08ο⊥ (8.62) |
Medication | |||
SABA/SAMA (yes/no) | 0/9 | 0/8 | 7/6 |
LABA/LAMA (yes/no) | 1/8 | 0/8 | 12/1 |
ICS (yes/no) | 1/8 | 0/8 | 8/5 |
Azithromycin (yes/no) | 0/9 | 0/8 | 3/10 |
OCS (yes/no) | 0/9 | 0/8 | 0/13 |
White blood cell differentiation | |||
Hemoglobin (g/dL) | 13.94 (0.93) | 13.73 (1.52) | 14.32 (1.12) |
White blood cells (10E3/μL) | 6.45 (1.55) | 7.34 (1.71) | 7.64 (1.54) |
Neutrophil (%) | 58.82 (6.83) | 62.84 (4.59) | 64.72 (11.55) |
Lymphocytes (%) | 32.87 (6.74) | 27.99 (4.10) | 26.49 (10.77) |
Monocytes (%) | 7.46 (2.51) | 7.34 (2.03) | 6.67 (1.94) |
Eosinophils (%) | 2.24 (1.02) | 1.36 (0.72) | 1.73 (1.12) |
Basophils (%) | 0.51 (0.24) | 0.42 (0.21) | 0.38 (0.21) |