Fig. 4
From: IL-10 producing regulatory B cells are decreased in blood from smokers and COPD patients
IL-6, IL-10, IL-35, and TGF-β levels in cell culture supernatant of stimulated PBMCs. Levels of different pro- and anti-inflammatory cytokines were determined in cell culture supernatant that was obtained after the 48 h in vitro stimulation period. Levels of different cytokines in healthy controls, smokers without airway obstruction, and COPD patients were determined: A levels of IL-6 in cell-culture supernatant, B levels of IL-10 in cell-culture supernatant, C Correlation between IL-10 levels in supernatant and IL-10 + B-regs in total B lymphocytes, D levels of TGF-β in cell-culture supernatant, E levels of IL-35 in cell-culture supernatant, and F Correlation between IL-10 and IL-35 levels in cell-culture supernatant