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Fig. 2 | Respiratory Research

Fig. 2

From: Influence of COPD systemic environment on the myogenic function of muscle precursor cells in vitro

Fig. 2

Transcript expression of myogenin (MYOG), actin alpha 1 (ACTA1) and myosin heavy chain-IIa (MHC2A) and -IIx (MHC2X) were assessed by real-time RT-PCR. (a) MPCs were induced to differentiate in the presence of differentiation medium containing 2% human serum obtained from control subjects (hu S CONTROL), stable COPD patients (hu S SCOPD) and COPD patients with an acute exacerbation (hu S AECOPD). Results are presented as the mean ± SD (n = 12): *p < 0.05, **p < 0.01 and ***p < 0.001 compared with hu S CONTROL group. †††p < 0.001 compared with hu S SCOPD group (b) Differentiation of MPCs in the presence of hu S AECOPD serum was assessed before and after methylprednisolone (MP) treatment in the absence or presence of the GCR antagonist Mifepristone (MIF). ##p < 0.01 and ###p < 0.001 compared with hu S AECOPD exposure before MP treatment; §§p < 0.01 and §§§p < 0.001 compared with hu S AECOPD exposure after MP treatment

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