Comparative transcriptomics in human COPD reveals dysregulated genes uniquely expressed in ferrets

Respiratory Research

Table 3 25 Smoke-related DEGs identified in the ferret and human lungs shown in order of statistically significance for the ferret study

FERRET	log₂FC	p-value	p_adj	Human	Wilcox p-value	Fold change
DHRS9	4.62	2.31E−65	3.80E−61	DHRS9	3.38E−08	1.70
LIPA	1.62	3.60E−35	7.41E−32	LIPA	1.40E−12	2.16
RAB7B	1.33	1.63E−30	2.43E−27	RAB7B	8.24E−09	1.52
TMEM92	1.30	1.38E−20	4.73E−18	TMEM92	3.28E−10	1.48
HSD17B14	1.37	1.28E−19	3.84E−17	HSD17B14	1.51E−12	1.69
C5AR1	1.17	1.42E−16	3.25E−14	C5AR1	4.37E−12	1.42
WDFY4	1.21	3.60E−16	7.90E−14	WDFY4	1.44E−07	1.29
IL18	1.03	5.78E−15	1.03E−12	IL18	2.26E−10	1.42
ALPL	1.33	2.34E−14	4.04E−12	ALPL	2.71E−09	1.39
CLEC7A	1.39	4.59E−14	7.62E−12	CLEC7A	2.62E−12	1.35
TMEM144	1.06	1.63E−13	2.50E−11	TMEM144	4.05E−11	1.38
TREM1	1.12	1.38E−12	1.84E−10	TREM1	2.24E−08	1.41
KBTBD8	1.31	1.14E−09	9.94E−08	KBTBD8	2.97E−09	1.61
GLDN	1.46	2.83E−07	1.57E−05	GLDN	2.28E−10	1.44
SRXN1	1.02	6.73E−07	3.38E−05	SRXN1	5.16E−08	1.36
GLS2	1.09	1.04E−06	4.97E−05	GLS2	2.46E−12	1.54
GZMA	1.81	1.36E−06	6.24E−05	GZMA	5.53E−08	0.65
RPP25	2.07	3.87E−06	1.61E−04	RPP25	4.64E−09	1.33
SNAP25	− 3.94	5.62E−05	1.63E−03	SNAP25	2.56E−09	2.10
KL	1.23	7.98E−04	1.43E−02	KL	1.80E−08	0.62
INSC	− 1.36	2.44E−03	3.37E−02	INSC	1.75E−07	0.72
PNPLA3	− 1.03	2.52E−03	3.46E−02	PNPLA3	7.50E−13	2.34
EGFLAM	− 1.15	2.75E−03	3.69E−02	EGFLAM	1.01E−06	1.52
MAL	− 1.17	9.75E−03	9.24E−02	MAL	2.72E−07	0.73
FANCE	1.07	1.07E−02	9.85E−02	FANCE	8.44E−11	1.30

The statistical metrics reported for the human are computed from the human smoking study [14]. The log₂FC is log₂ fold change; the p_adj is adjusted p-value. Genes listed in bold are discordant between ferret and human

ISSN: 1465-993X