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Table 3 Results of univariate, multivariate, and IPW-adjusted survival analyses for in-hospital mortality in patients with early or non-early tapering steroid group

From: Early corticosteroid dose tapering in patients with acute exacerbation of idiopathic pulmonary fibrosis

 

Multi-center cohort data

Administrative cohort data

 

crude HR (95% CI)

adjusted HR (95% CI)

crude HR (95% CI)

adjusted HR (95% CI)

Univariate analysis

0.41 (0.22, 0.76)

−

0.65 (0.36, 1.18)

−

Main analysis

(IPW-adjusted survival analysis)

−

0.37 (0.14, 0.99) *

−

0.27 (0.094, 0.83) †

Sensitivity analysis 1

(IPW-adjusted survival analysis) ††

−

0.28 (0.078, 0.98) *

−

0.35 (0.12, 1.04) †

Sensitivity analysis 2

(Cox proportional hazard model)

−

0.36 (0.18, 0.72) ¶

−

−

Sensitivity analysis 3

(Cox proportional hazard model)

−

0.41 (0.19, 0.87) §

−

0.59 (0.31, 1.13) §

  1. * IPW was calculated using a logistic regression model that includes age, sex, LDH level, CRP level, albumin level, KL-6 level, CCI ( ≦ 2, 3 or 4, ≧5), LDH level on day 7 (± 3) of admission, CRP level on day 7 (± 3) of admission, albumin level on day 7 (± 3) of admission, LTOT before AE (yes, no), PaO2/FiO2, SpO2/FiO2 on day 7 (± 3) of admission, HRCT score, change in imaging findings at day 7 (± 3) of admission (improvement, stable or worsening), steroid administration before admission (yes, no), immunosuppressant administration before admission (yes, no), steroid pulse therapy (yes, no), initial steroid dose (low, moderate, high), and immunosuppressant after admission (yes, no)
  2. † IPW was calculated using a logistic regression model that includes age, sex, LDH level, CRP level, albumin level, KL-6 level, CCI ( ≦ 2, 3 or 4, ≧5), LDH level on day 7 (± 3) of admission, CRP level on day 7 (± 3) of admission, albumin level on day 7 (± 3) of admission, steroid administration before admission (yes, no), immunosuppressant administration before admission (yes, no), steroid pulse therapy (yes, no), initial steroid dose (low, moderate, high), and immunosuppressant after admission (yes, no)
  3. †† After excluding patients who died or were discharged within 10 days after admission
  4. ¶ Adjusted for age, sex, LTOT before AE (yes, no), HRCT score, PaO2/FiO2, SpO2/FiO2 on day 7 (± 3) of admission, and changes in imaging findings on day 7 (± 3) of admission (improve, stable or worsening)
  5. § Adjusted for age, sex, LDH level, CRP level, CCI ( ≦ 2, 3 or 4, ≧5), LDH level on day 7(± 3) of admission, and CRP on day 7 (± 3) of admission
  6. AE, acute exacerbation; CCI, Charlson Comorbidity Index; CRP, C reactive protein; CI, confidence interval; FiO2, fraction of inspired oxygen; HR, hazard ratio; HRCT, high-resolution computed tomography; IPW, inverse probability weighting; KL-6, Krebs von den Lugen-6; LDH, lactate dehydrogenase; LTOT, long-term oxygen therapy; PaO2, arterial oxygen tension; SpO2, peripheral oxygen saturation
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Respiratory Research

ISSN: 1465-993X

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