Table 1 Subjects’ baseline characteristics
A | |||
|---|---|---|---|
Demographic | Control subjects | Young COPD ≤ 50 years | p-value |
N | 125 | 160 | |
Age (mean, SD) | 43 ± 5 | 46 ± 4 | 0.0001 |
Male (%) | 52% | 76% | < 0.0001 |
Current smoker (%) | 76% | 61% | 0.001 |
Pack-years (mean, SD) | 28 ± 14 | 49 ± 31 | 0.0001 |
FEV1/FVC (mean, SD) | 0.81 ± 0.05 | 0.57 ± 0.15 | < 0.0001 |
FEV1% predicted (mean, SD) | 101 ± 2 | 61 ± 2 | < 0.0001 |
BMI (Kg/m2) (mean, SD) | 26.4 ± 4.9 | 26.2 ± 5.8 | 0.9181 |
B | |||
|---|---|---|---|
Demographic | Young COPD ≤ 50 years | Old COPD > 50 y/o | p-value |
N | 160 | 1860 | |
Age (mean, SD) | 46 ± 4 | 68 ± 8 | < 0.0001 |
Male (%) | 76% | 90% | < 0.0001 |
Current smoker (%) | 61% | 32% | < 0.0001 |
Pack-years | 49 ± 31 | 76 ± 45 | < 0.0001 |
FEV1/FVC (mean, SD) | 0.57 ± 0.15 | 0.49 ± 0.14 | < 0.0001 |
FEV1% predicted (mean, SD) | 61 ± 27 | 51 ± 21 | < 0.0001 |
GOLD categories (all with FEV1/FVC < 0.70) | |||
GOLD I (FEV1 ≥ 80%) | 15% | 10% | 0.2842 |
GOLD II (FEV1 50–79%) | 33% | 39% | |
GOLD III (FEV1 30–49%) | 33% | 36% | |
GOLD IV (FEV1 < 30%) | 19% | 15% | |
BMI (kg/m2) (mean, SD) | 26.2 ± 5.8 | 27.3 ± 5.4 | 0.0289 |
BODE score (mean, SD) | 2.9 ± 2.4 | 3.4 ± 2.6 | 0.1012 |
BODE score 0 to 2 | 48% | 42% | 0.3393 |
BODE score 3 and 4 | 29% | 26% | |
BODE score 5 and 6 | 13% | 17% | |
BODE score 7 to 10 | 10% | 15% | |