Fig. 3

Representation of the “Comorbidomes” for both the Young COPD patients ≤ 50 years (A) and Old COPD > 50 years of age (B). The bubbles’ sizes are proportional to the comorbidity prevalence, and the distance to the center is proportional to the inverse of the hazard ratio (1/HR) for death; the closer to the center, the higher is the association with death. See Table 2 for actual hazard ratio values. The comorbidities represented are those with significant association to death, and the dotted circular line represents the cut-off of statistical significance set at p < 0.05 for the hazard ratio