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Table 4 Hazard ratios for exacerbations in subgroups stratified by the index date

From: Effect of timing of bronchodilator therapy initiation on exacerbations in patients with chronic obstructive pulmonary disease: a retrospective cohort study

 

Exacerbation (n/N)

Hazard ratio (95% CI)a

Prompt therapy group

Delayed therapy group

Unadjusted

Adjusted

Index date after November 1, 2013

30.5 (185/607)

46.3 (177/382)

0.65 (0.53, 0.80)

0.64 (0.52, 0.79)

Index date after April 1, 2018

17.6 (12/68)

27.6 (8/29)

0.56 (0.23, 1.39)

0.55 (0.21, 1.42)

  1. COPD chronic obstructive pulmonary disease, CI confidence interval
  2. aCalculated by Cox proportional hazards model
  3. Covariates in pre-index period include age, sex, number of comorbidities, use of systemic corticosteroids, use of antibiotics, and number of hospitalizations excluding hospitalization due to COPD exacerbation or acute respiratory failure
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Respiratory Research

ISSN: 1465-993X

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