Table 3 Annual moderate or severe exacerbation rate ratios
Treatment initiation group (n) | Follow-up period (person-years) | Number of exacerbations | Rate (95% CI)a | Rate ratio (95% CI)a | ||
|---|---|---|---|---|---|---|
Unadjusted | Adjusted | |||||
Full analysis set | Delayed (1516) | 9491.1 | 2418 | 0.30 (0.28, 0.33) | Reference | Reference |
Prompt (1466) | 6822 | 1287 | 0.22 (0.20, 0.25) | 0.74 (0.65, 0.84) | 0.71 (0.62, 0.80) | |
By phenotype | ||||||
Chronic bronchitis | Delayed (572) | 3631.7 | 1065 | 0.33 (0.30, 0.37) | Reference | Reference |
Prompt (185) | 900.9 | 192 | 0.26 (0.21, 0.33) | 0.78 (0.60, 1.02) | 0.75 (0.58, 0.79) | |
Emphysema | Delayed (652) | 4273.7 | 986 | 0.29 (0.25, 0.33) | Reference | Reference |
Prompt (671) | 3505.9 | 577 | 0.20 (0.17, 0.23) | 0.69 (0.57, 0.84) | 0.69 (0.57, 0.83) | |
Unclassified | Delayed (384) | 2206.8 | 507 | 0.27 (0.23, 0.33) | Reference | Reference |
Prompt (774) | 3199.6 | 710 | 0.25 (0.22, 0.29) | 0.92 (0.73, 1.15) | – (–, –) | |