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Table 2 Hazard ratios for exacerbations

From: Effect of timing of bronchodilator therapy initiation on exacerbations in patients with chronic obstructive pulmonary disease: a retrospective cohort study

 

Exacerbation (n/N)

Hazard ratio (95% CI)a

Prompt therapy group

Delayed therapy group

Unadjusted

Adjusted

Full analysis set

37.7 (552/1466)

58.4 (885/1516)

0.78 (0.70, 0.87)

0.72 (0.65, 0.81)

By phenotype

 Chronic bronchitis

40.5 (75/185)

64.2 (367/572)

0.72 (0.56, 0.92)

0.70 (0.54, 0.90)

 Emphysema

38.7 (260/671)

56.6 (369/652)

0.81 (0.69, 0.96)

0.80 (0.68, 0.94)

 Unclassified

37.3 (289/774)

53.6 (206/384)

0.91 (0.76, 1.09)

0.82 (0.68, 0.99)

  1. COPD chronic obstructive pulmonary disease, CI confidence interval
  2. aCalculated by Cox proportional hazards model
  3. Covariates in pre-index period include age, sex, number of comorbidities, use of systemic corticosteroids, use of antibiotics, and number of hospitalizations excluding hospitalization due to COPD exacerbation or acute respiratory failure
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Respiratory Research

ISSN: 1465-993X

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