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Table 2 Identified clusters, annotated cell type, representative genes and their corresponding proportions

From: Combining single-cell RNA sequencing of peripheral blood mononuclear cells and exosomal transcriptome to reveal the cellular and genetic profiles in COPD

Cluster

Cell type

Representative genes

Proportion

0

CD4 + Tn

CCR7, LEF1

16.01%

5

CD4 + Trm

NR4A2, IL7R, PTGER4

7.79%

8

CD4 + Tm

S100A4, LTB

6.17%

1

CD8 + Temra

PRF1, KLRG1, GZMH

12.91%

2

CD8 + Tem

GZMK

10.53%

7

CD8 + Tn

CCR7, LEF1

6.25%

3

Natural killer cell

GNLY, NKG7

8.04%

11

Natural killer cell

GNLY, NKG7

3.52%

4

B cell

IGKC

7.94%

9

B cell

IGHD

5.52%

10

B cell

MS4A1

3.73%

6

Classical Monocyte

CD14, S100A9, LYZ

6.30%

14

Nonclassical Monocyte

CD16, FCGR3A, TCF7L2

0.64%

15

Monocyte

CD14, CLEC12A

0.43%

12

Megakaryocyte

PPBP, PF4

2.64%

13

Myeloid dendritic cell

HLA-DRB1, HLA-DRB5

0.87%

16

Plasmacytoid dendritic cell

IRF7, IRF8

0.43%

17

STMN + T cell

CD3D, STMN

0.28%

  1. Tn Naïve T cell, Trm resident memory T cell, Tm memory T cell, Temra effector memory RA + T cell, Tem effector memory T cell