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Table 1 Univariate regression analyses, predictors of in-hospital mortality

From: Machine learning-derived prediction of in-hospital mortality in patients with severe acute respiratory infection: analysis of claims data from the German-wide Helios hospital network

Variable

In-hospital mortality, n (% of patients with the same variable expression)

Odds Ratio (95% CI)

P-value

N (total)

28,025 (11.6)

  

Age

   

  < 65

3835 (4.5)

  

 65–74

5,025 (12.8)

3.086 (2.953–3.224)

 < 0.001

  ≥ 75

19,165 (16.2)

4.047 (3.904–4.195)

 < 0.001

Gender

   

 Female

11,317 (10.7)

  

 Male

16,708 (12.3)

1.172 (1.143–1.202)

 < 0.001

ICU treatment

   

 No

16,789 (8.1)

  

 Yes

11,236 (31.6)

5.206 (5.065–5.35)

 < 0.001

Hospital-acquired SARI

   

 No

15,922 (8.2)

  

 Yes

12,103 (25)

3.712 (3.616–3.81)

 < 0.001

Influenza

   

 No

27,514 (11.9)

  

 Yes

511 (5)

0.39 (0.356–0.427)

 < 0.001

Viral pneumonia other than influenza

   

 No

27,957 (11.7)

  

 Yes

68 (1.9)

0.144 (0.113–0.183)

 < 0.001

Bacterial pneumonia

   

 No

20,658 (10.1)

  

 Yes

7367 (19.5)

2.158 (2.096–2.222)

 < 0.001

Other pneumonia

   

 No

8,700 (8.3)

  

 Yes

19,325 (14.1)

1.818 (1.77–1.867)

 < 0.001

Other lower respiratory tract infections

   

 No

26,163 (14.3)

  

 Yes

1862 (3.2)

0.196 (0.187–0.206)

 < 0.001

Congestive heart failure

   

 No

13,466 (8.4)

  

 Yes

14,559(17.8)

2.355 (2.296–2.415)

 < 0.001

Cardiac arrhythmias

   

 No

15,068 (9)

  

 Yes

12,957 (17.2)

2.1 (2.047–2.153)

 < 0.001

Valvular disease

   

 No

23,300 (10.9)

  

 Yes

4725 (16.6)

1.621 (1.567–1.677)

 < 0.001

Pulmonary circulation disorders

   

 No

24,752 (11.1)

  

 Yes

3273 (16.7)

1.595 (1.533–1.66)

 < 0.001

Peripheral vascular disorders

   

 No

23,501 (10.8)

  

 Yes

4524 (18.9)

1.922 (1.856–1.991)

 < 0.001

Hypertension, uncomplicated

   

 No

17,555 (11.3)

  

 Yes

10,470 (12.1)

1.076 (1.049–1.104)

 < 0.001

Hypertension, complicated

   

 No

22,929 (11.3)

  

 Yes

5096 (13.1)

1.186 (1.148–1.225)

 < 0.001

Paralysis

   

 No

25,057 (11.1)

  

 Yes

2968 (18.9)

1.871 (1.794–1.951)

 < 0.001

Other neurological disorders

   

 No

23,197 (10.7)

  

 Yes

4828 (18.6)

1.905 (1.841–1.971)

 < 0.001

Chronic pulmonary disease

   

 No

22,520 (11.5)

  

 Yes

5505 (12)

1.051 (1.018–1.084)

0.002

Diabetes, uncomplicated

   

 No

23,342 (11.1)

  

 Yes

4683 (14.4)

1.343 (1.298–1.389)

 < 0.001

Diabetes, complicated

   

 No

23,436 (11)

  

 Yes

4589 (15.9)

1.527 (1.476–1.581)

 < 0.001

Hypothyroidism

   

 No

25,383 (11.6)

  

 Yes

2642 (11.2)

0.956 (0.917–0.998)

0.041

Renal failure

   

 No

14,923 (9.5)

  

 Yes

13,102 (15.6)

1.764 (1.72–1.808)

 < 0.001

Liver disease

   

 No

25,094 (10.9)

  

 Yes

2931 (23.7)

2.525 (2.418–2.637)

 < 0.001

Metastatic cancer

   

 No

24,609 (10.7)

  

 Yes

3416 (27.4)

3.147 (3.019–3.281)

 < 0.001

Solid tumor without metastasis

   

 No

22,839 (10.4)

  

 Yes

5,186 (23.5)

2.653 (2.564–2.744)

 < 0.001

Coagulopathy

   

 No

23,269 (10.2)

  

 Yes

4756 (32.4)

4.21 (4.056–4.369)

 < 0.001

Obesity

   

 No

25,187 (11.7)

  

 Yes

2838 (10.5)

0.879 (0.844–0.916)

 < 0.001

Weight loss

   

 No

20,416 (9.8)

  

 Yes

7609 (22.4)

2.655 (2.578–2.734)

 < 0.001

Fluid and electrolyte disorders

   

 No

10,342 (7.5)

  

 Yes

17,683 (16.9)

2.51 (2.446–2.575)

 < 0.001

Depression

   

 No

26,686 (11.7)

  

 Yes

1339 (10.1)

0.854 (0.806–0.905)

 < 0.001

  1. ICU Intensive care unit, SARI severe acute respiratory infection