Fig. 2
From: Chronic air pollution-induced subclinical airway inflammation and polygenic susceptibility
Effects of air pollutant exposure on airway inflammatory biomarkers for each IQR-increase of the PRS. loge-tumor necrosis factor-α (TNF-α), loge-leukotriene (LT) B4, loge-total number of cells = the sum of eosinophils, macrophages, neutrophils and epithelial cells, NO2 = nitrogen dioxide, NOx = nitrogen oxides, PM2.5/10/coarse = particulate matter with aerodynamic diameters ≤ 2.5/ ≤ 10/ 2.5–10 µm, PM2.5 absorbance = reflectance of PM2.5 filters, IQR interquartile range, PRS polygenic risk score, dashed line indicates beta estimate = 0. Individual weighted polygenic risk scores (normally distributed) derived by the interaction-training approach, standardized using interquartile ranges. Air pollutants: the mean of the annual average concentrations from baseline and first follow-up examinations within a time window of 15 years prior to the airway inflammatory biomarker assessments, statistically centred across the participants, standardized using interquartile ranges. Adjusted for: age, body mass index (BMI in kg/m2), highest education of the participant or her spouse, ever-/never-smoking and second-hand smoking