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Table 5 Association between paternal age at birth (categorical) and lung function

From: Association of advanced paternal age with lung function at school age

 

Crude coefficient β (95% CI)a

Adjusted coefficient β (95% CI)a

 

30–34 years ( n = 566)

35–39 years ( n = 398)

≥ 40 years ( n = 159)

30–34 years ( n = 566)

35–39 years ( n = 398)

≥ 40 years ( n = 159)

FVC (mL)

20.51 (− 17.36, 58.37)

− 19.17 (− 59.10, 20.77)

9.17 (− 40.16, 58.50)

15.32 (− 12.17, 42.80)

− 16.50 (− 45.9, 12.9)

16.49 (− 21.64, 54.62)

FEV1 (mL)

4.62 (− 30.02, 39.25)

− 30.02 (− 66.55, 6.51)

− 21.20 (− 66.32, 23.92)

− 1.16 (− 26.69, 24.37)

− 28.56  (− 55.87, − 1.24) *

− 20.50 (− 55.93, 14.93)

FEV1/FVC (%)

− 1.06  (− 2.06, − 0.06) *

− 1.15  (− 2.21, − 0.09) *

− 2.29  (− 3.60, − 0.98) *

− 1.15  (− 2.20, − 0.09) *

− 1.20  (− 2.33, − 0.08) *

− 2.93  (− 4.38, − 1.47) *

FEF75 (mL/s)

− 34.55 (− 77.52, 8.43)

− 55.56  (− 100.88, − 10.24) *

− 92.81  (− 148.80, − 36.83) *

− 34.11 (− 76.33, 8.11)

− 50.78  (− 95.95, − 5.61) *

− 99.08  (− 157.66, − 40.5) *

PEF (mL/s)

− 43.32 (− 142.24, 55.61)

− 97.48 (− 201.80, 6.85)

− 124.87 (− 253.74, 4.01)

− 41.62 (− 132.31, 49.08)

− 88.73 (− 185.76, 8.30)

− 115.26 (− 241.11, 10.58)

FeNO (ppb)

1.29 (− 1.62, 4.20)

0.78 (− 2.29, 3.84)

0.63 (− 3.14, 4.40)

0.38 (− 2.64, 3.40)

0.06 (− 3.16, 3.28)

− 0.24 (− 4.40, 3.92)

  1. CI confidence interval, FVC forced vital capacity, FEV1 forced expiratory volume in 1 s, FEF75 forced expiratory flow at 75% of FVC, PEF peak expiratory flow, ppb parts per billion
  2. aReference group was paternal age at birth < 30 years, adjusting for age, sex, height, maternal age at birth, prematurity, birth weight, cesarean delivery, birth order, physician-diagnosed asthma, parental university education, parental allergic diseases, prenatal exposure to environmental tobacco smoke, breastfeeding, and household income
  3. *P < 0.05 is bold