Table 1 Enzymatic activity and functions of sirtuins
Sirtuin | Enzymatic functions | Biological functions in asthma |
|---|---|---|
SIRT1 | Deacetylase | Both protective and deleterious roles in asthma |
SIRT2 | Deacetylase | Pro-inflammatory role |
SIRT3 | Deacetylase | Protective role in asthma |
SIRT4 | Mono-ADP-ribosylase Lipoamidase Deacylase | / |
SIRT5 | Deacetylase Deglutarylase Demalonylase Desuccinylase | / |
SIRT6 | Deacetylase defatty-acylase Mono-ADP-ribosylase | Protective role in asthma |
SIRT7 | Deacetylase Desuccinylase Deglutarylase | Promotes proliferation and migration of airway smooth muscle cells |