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Table 2 Participant characteristics and P-GRS profiles

From: Peroxisome proliferator-activated receptor gamma gene variants modify human airway and systemic responses to indoor dibutyl phthalate exposure

Participant

Sex

Age

Baseline FEV1 (% predicted)

Baseline methacholine PC20 (mg/ml)

P-GRS

1

F

23

76

0.3

− 0.02

2

F

33

88

1.7

0

3

M

29

96

2

− 0.36

4

F

46

79

2.9

0

5

F

45

102

6.9

− 0.05

6

F

45

N/A*

9.1

− 0.05

7

M

36

99

14.5

− 0.38

8

M

27

93

16

− 0.02

9

F

21

95

47.9

0

10

F

34

91

64

− 0.09

11

F

21

99

121.1

− 0.05

12

M

26

94

147.1

0

13

F

26

108

149.3

− 0.38

14

F

29

117

301

− 0.05

15

M

31

74

491.5

− 0.36

16

M

26

101

1067

− 0.05

Summary

M = 6

F = 10

31 ± 8#

94 ± 12#

AHR = 8†

− 0.12 ± 0.15#

  1. N/A  not available, FEV1  forced expiratory volume in 1 s, PC20  provocative concentration of methacholine causing a 20% drop in FEV1, P-GRS  PPARG genetic risk score, calculated as the weighted additive effects of minor alleles of 3 selected SNPs. #Mean ± SD. *Baseline spirometry not available for this participant. Baseline lung function measurements were taken at the time of study recruitment. †Airway hyperresponsiveness (AHR) status defined as provocative concentration of methacholine resulting in 20% drop in FEV1 [PC20] ≤ 16 mg/ml