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Fig. 4 | Respiratory Research

Fig. 4

From: Peroxisome proliferator-activated receptor gamma gene variants modify human airway and systemic responses to indoor dibutyl phthalate exposure

Fig. 4

Exposure-by-P-GRS interaction on DBP effect on lung function outcomes. Lung function outcomes included: A FEV1 (% predicted), ∆20 h; B Methacholine challenge (LogPC20), 20 h; C FeNO, ∆20 h; D Allergen AUC, 3 h. The listed time points refer to the time after the allergen challenge post-DBP or CA exposure. FEV1  forced expiratory volume in one second, PC20 concentration leading to 20% fall in FEV1, FeNO  fractional exhaled nitric oxide, AUC  area under curve, measured as percent decline in FEV1 spanning baseline to 3 h after allergen challenge. The histogram underlying each plot illustrates the distribution of the participants’ P-GRS. Effect values represent the DBP-attributable difference between the measurement at the given time point and the baseline. The solid line represents the interaction effect, with the p value corresponding to the interaction significance. The shaded region represents 95% confidence intervals

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