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Table 2 Immunohistochemical and histopathological findings for the effects of on oleic acid-induced acute lung injury

From: Effects of tocilizumab and dexamethasone on the downregulation of proinflammatory cytokines and upregulation of antioxidants in the lungs in oleic acid-induced ARDS

  

CN

OA

OA + TCZ-2

OA + TCZ-4

OA + DEX-10

P-value

Histopathological

Thickening in the interalveolar septum

0.60 ± 0.54b

2.40 ± 0.54a

1.40 ± 0.54ab

1.00 ± 0.70b

0.80 ± 0.44b

0.006

Peribronchial cell infiltration

0.60 ± 0.54b

2.88 ± 0.40a

1.20 ± 0.44b

1.00 ± 0.70b

1.00 ± 0.70b

0.006

Hyperemia in vessels

1.20 ± 0.44b

2.60 ± 0.54a

1.40 ± 0.54b

1.40 ± 0.89b

1.40 ± 0.54b

0.039

Immunohistochemical

TNF-a

0.50 ± 0.57b

2.75 ± 0.50a

1.75 ± 0.95ab

2.5 ± 1.00ab

1.5 ± 1.00ab

0.034

IL-6

1.00 ± 1.15b

2.50 ± 0.57a

1.25 ± 0.5ab

0.50 ± 0.57b

0.75 ± 0.50b

0.41

IL-8

0.75 ± 0.50b

2.5 ± 0.57a

2.00 ± 0.81ab

0.25 ± 0.50b

0.75 ± 0.95b

0.13

  1. a, bP < 0.05. All values are given as mean ± standard deviation